稀土壳聚糖配合物的制备、表征和抑菌性能研究  

Preparation,Characterization and Antibacterial Properties of Chitosan2 RE(Ⅲ) Complexes

作　　者：杨自芳[1] 何其庄[1] 许东芳[1] 沈智慧[1] 沈敬一[1] 夏庆春[1] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200234

出　　处：《稀土》2009年第6期50-54,共5页Chinese Rare Earths

基　　金：国家自然科学基金项目资助(20671063);上海市稀土功能材料重点实验室(07dz22303);上海市科委纳米技术专项(0652nm045);上海师范大学重点学科项目资助(DZL711)

摘　　要：以天然高分子壳聚糖和稀土硝酸盐为原料,室温下,壳聚糖与稀土硝酸盐溶液在稀醋酸中反应,制得一系列新型稀土壳聚糖配合物。通过红外光谱、X射线能谱、差热-热重、X射线光电子能谱、透射电镜等对合成物进行分析、表征。所合成的配合物由分散的纳米粒子组成。并采用培养基扩散法、营养肉汤稀释法等抑菌实验方法对其进行了抑菌活性研究,结果表明其对大肠杆菌和金黄色葡萄球菌均有很好的抑菌作用,最小抑菌浓度（MIC）在200μg.mL^-1-300μg.mL^-1范围内,低于800μg.mL^-1,且抑菌效果明显优于单独的壳聚糖、稀土硝酸盐。The powder of rare earth chitosan was prepared by using the natural polymer-chitosan and rare earth nitrate in dilute acetic acid and was characterized by FTIR,EDS,TG-DTA,XPS and TEM.The TEM image indicated that the compounds were consisted of dispersed particles with nano size.The antibacterial activity test showed that rare earth chitosan exhibited excellent antibacterial ability against Escherichia coli and Staphylococcus aureus.The minimum inhibitory concentration was about 200μg·mL^-1～300μg·mL^-1.Rare earth chitosan distincted excelled individual chitosan and the rare earth nitrate in antibacterial activity.The antimicrobial spectra of the compounds are broad.

关 键 词：稀土 壳聚糖 配合物 抑菌性能 

分 类 号：O614.33[理学—无机化学] O626.3[理学—化学]