小剂量雄激素治疗少弱精子症的临床研究  

Clinical study of a small dose of androgen for the treatment of oligo-asthenospermatism

作　　者：何学酉[1] 李钢[1] 张旭[1] 姜辉[2] 赵连明[2] 戴东曦[3] 谢毅[3] 

机构地区：[1]中国人民解放军总医院泌尿外科,北京100853 [2]北京医科大学第三附属医院泌尿外科 [3]北京朝阳医院男科

出　　处：《中国男科学杂志》2009年第12期42-45,48,共5页Chinese Journal of Andrology

摘　　要：目的评估小剂量雄激素治疗男性少弱精子症的有效性和安全性。方法采用多中心、随机、单盲、安慰剂对照的方法,对129例患者进行了疗程3月的临床研究。结果治疗后,雄激素组患者的精液量、精子活力、精子活率、精子果糖、血睾酮升高,精子畸形率降低,差异有统计学意义;而安慰剂组患者的上述指标均无统计学差异。结论小剂量雄激素补充治疗可显著提高少弱精子症患者的精液量、精子活力、精子活率、精浆果糖和血睾酮,降低精子畸形率。Objective To investigate the effect of a small quantity of androgen for the treatment of oligo- asthenospermatism. Methods A total of 129 patients with oligo-asthenospermatism were enrolled in the multicentre, randomized, single-blind, placebo-controlled clinical trial with treatment by either testosterone undecanoate or placebo for 3 months. Results There were significant increase in semen volume, motility and survival rate of sperm, fructose level of seminal plasma and testosterone level of plasma, and decrease in teratosperm rate in patients of androgen group, whereas there were no significant differences in patients of placebo group. Conclusion Patients with oligo- asthenospermatism can gain significant increase in semen volume, motility and survival rate of sperm, fructose level of seminal plasma and testosterone level of plasma, and decrease in teratosperm rate after the treatment of a small dose of androgen.

关 键 词：弱精子症 少精子症 雄激素类 

分 类 号：R698.2[医药卫生—泌尿科学]