锰神经毒性的病理生理学研究  

Pathophysiologic Study of Manganese Neurotoxicity

作　　者：吴飞盈[1] 廖海涛[1] 韦义萍[1] 姜岳明[2] 

机构地区：[1]广西医科大学护理学院,广西南宁530021 [2]广西医科大学公共卫生学院,广西南宁530021

出　　处：《铁道劳动安全卫生与环保》2009年第6期292-295,共4页Railway Occupational Safety Health & Environmental Protection

基　　金：国家自然科学基金项目(30760210);广西自然科学基金(0991129);广西教育厅研究生教育创新计划(2008105981004D32)

摘　　要：慢性锰暴露可能引起多巴胺能功能选择性障碍、谷氨酸能运输系统受损、活性氧产生、"外周型"苯二氮卓类受体结合位点增加、参与糖分解的三磷酸甘油醛脱氢酶及其它酶类代谢异常,导致能量代谢变化、细胞形态改变、神经元损伤及细胞外谷氨酸浓度增加,这对于从病理生理学角度阐明锰神经毒性机制具有十分重要的作用。Chronic exposure to manganese causes selective dopaminergic dysfunction,impairment of glutamate transport,production of active oxygen,increased densities of binding sites for the ＂peripheral-type＂ benzodiazepine receptor,alterations of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase and abnormal metabolism of other enzymes.Such effects can lead to changed energy metabolism,altered cellular morphology,damaged neurons and increased extracellular glutamate concentration.It plays a very important role to clarify the pathophysiologic mechanism of manganese neuroxicity.

关 键 词：锰 神经毒性 病理生理学 

分 类 号：R135.1[医药卫生—劳动卫生]