劳拉西泮结合心理干预治疗广泛性焦虑症的疗效观察  

Efficacy of Lorazepam Combined with Psychological Intervention in Generalized Anxiety Disorder

作　　者：张学志[1] 谷岩[2] 于振剑[2] 王刚[2] 姜宝顺[2] 王长奇[2] 

机构地区：[1]河北省唐山市第五医院,中国063000 [2]华北煤炭医学院附属开滦精神卫生中心

出　　处：《中国健康心理学杂志》2009年第12期1430-1431,共2页China Journal of Health Psychology

摘　　要：目的探讨劳拉西泮结合心理干预在治疗广泛性焦虑症的疗效。方法将66例符合CCMD-3诊断的广泛性焦虑性神经症患者,随机分为两组,其中对照组33例,单用劳拉西泮治疗;研究组33例,为劳拉西泮结合心理干预联合治疗,两组疗程均为8周,于治疗前、治疗2、4、6、8周末以及半年后随访时分别用焦虑自评量表(SAS)和汉密尔顿焦虑量表(HAMA)评定疗效。结果治疗2周末两组SAS和HAMA评分均较治疗前有非常明显的下降(P<0.01);治疗6周末两组间SAS和HAMA评分开始有显著性差异(P<0.05);半年后随访,两组间SAS和HAMA评分以及复发率均有非常显著的差异(P<0.01)。结论劳拉西泮结合心理干预治疗广泛性焦虑症的疗效更好,尤其是远期疗效效果显著,推荐药物与心理联合治疗。Objective To investigate the efficacy of lorazepam combined with psychological intervention in Generalized Anxiety Disorder （GAD）. Methods A total of 66 patients who met CCMD-3 for GAD were randomly divided into two groups： control group contained 33 cases treated with single lorazepam; study group contained 33 cases treated with the combinative treatment of lorazepam and psychological intervention. Both of the two groups were treated for eight weeks, and evaluated with self-rating anxiety scale （SAS） and Hamilton Anxiety Scale （HAMA） in pre-treatment, 2,4, 6, 8 weeks after treatment, and six months after treatment, respectively.Results The SAS and HAMA scores of both groups significantly declined （P〈0.01） at the end of the second week than in pre-treatment; two groups＇ scores were significantly different since the end of the sixth week （P〈0.05）; and after six months follow-up, their scores and relapse rates were very significantly different （P〈0.01）. Conclusion Lorazepam combined with psychological intervention in GAD had better efficacy, in particular had better long-term efficacy, which should be strongly recommended in clinical use.

关 键 词：劳拉西泮 心理干预 广泛性焦虑症 

分 类 号：R563.1[医药卫生—呼吸系统] R749.72[医药卫生—内科学]