长时程增强及长时程抑制与全麻药关系的研究进展  

Progress in research of long-term potentiation and long-term depression with general anesthetics

作　　者：刘媛媛[1] 闵苏[1] 

机构地区：[1]重庆医科大学附属第一医院麻醉科,400016

出　　处：《国际麻醉学与复苏杂志》2009年第6期548-550,共3页International Journal of Anesthesiology and Resuscitation

摘　　要：长时程增强（long-term potentation，LTP）和长时程抑制（long-term depression，LTD）作为突触可塑性的两种不同表达方式，是学习记忆活动的细胞水平的生物学基础，与记忆的形成和维持有关。近年来许多研究表明，全身麻醉药的遗忘、镇静催眠及镇痛等效应与影响神经系统的突触可塑性即LTP和LTD有密切的关系。现就近年来LTP及LTD与全身麻醉药之间的最新进展作一综述。Long-term potentiation（LTP）and long-term depression（LTD）as the biological foundament of learning and memory at cellular leval are two different expressions of synaptie plasticity,which are both relevant to the formation of learning and memory. Many recent researches have shown that the effects of general anesthetics such as amnesia, sedation, hypnosis and analgesia did have close relationship with LTP and LTD. This review will focus on the progress in research of long-term potentiation and long-term depression with general anesthetics.

关 键 词：长时程增强 长时程抑制 全身麻醉药 学习记忆 镇痛 

分 类 号：R614.2[医药卫生—麻醉学]