TAT蛋白转导结构域的研究进展  

Current status of HIV-TAT protein trausduction domain

作　　者：岳立辉[1] 郭娜[1] 赵砚丽[1] 

机构地区：[1]河北省人民医院麻醉科,石家庄050051

出　　处：《国际麻醉学与复苏杂志》2009年第6期580-582,538,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金资助项目（30672024）

摘　　要：目前，应用基因重组技术人工合成治疗性蛋白质分子已经成为可能。但如何有效地将合成的蛋白质转运进入目标组织和细胞仍是当前需要解决的重大难题。蛋白转导结构域HIV-TAT的发现为体内外转运蛋白质进入细胞提供了新思路。近年来蛋白转导结构域转运蛋白质进入细胞的有效性以及其在疾病治疗中的价值已经得到不断证实。现主要对蛋白转导结构域HIV-TAT的研究进展作一综述。At present, it is possible to produce a given protein molecule by recombinant DNA technology for in vivo therapeutic applications. Nevertheless, it still remains a challenge to deliver the recombinant proteins to desired targets. However, discovery of the HIV-TAT protein transduction domain （PTD） has opened novel avenues for directing in vitro and in vivo delivery of proteins into cells. Protein transduction with PTDs over the past several years has been shown to be an effective way of delivering proteins in vitro and now several reports have also shown valuable in vivo applications in correcting disease states. In the present review we discuss the current status of the PTDs focusing mainly on the HIV TAT.

关 键 词：蛋白转导结构域 HIV-TAT 

分 类 号：R341[医药卫生—基础医学]