模拟瞳孔阻滞及虹膜膨隆的实验系统和方法  

Experimental System and Method to Research Pupil-blocking and Passive Deformation of Iris Tissue

作　　者：薄雪峰[1] 曹海勇[1] 杨进[1] 谈炎[1] 田新[1] 全海英[1] 刘志成[1] 

机构地区：[1]首都医科大学生物医学工程学院生物医学仪器学系

出　　处：《首都医科大学学报》2009年第6期809-811,共3页Journal of Capital Medical University

基　　金：国家自然科学基金(30600150;30670514);北京市教育委员会科技发展计划项目(KM200710025009;KZ200710011010);北京市科技新星培养计划(2007A076)资助项目~~

摘　　要：目的在不破坏虹膜环状形态结构及保持虹膜组织活性的前提下,设计一种模拟瞳孔阻滞及虹膜膨隆的实验系统和一种测量虹膜组织在前后房压强变化的情况下发生膨隆变形的实验方法。方法对原有实验装置进行改进,建立虹膜小试样微变形的双目立体测量图像采集系统,获得兔虹膜组织随前后房压强变化而膨隆变形的二维图像序列,利用立体视觉技术计算虹膜组织随压强变化而膨隆变形的三维空间坐标。将代表虹膜膨隆高度的Z轴数据进行平均并进行曲线拟合,得到表征虹膜膨隆高度与前后房压强差之间关系的曲线。结果获得模拟前后房压强差分别为50、100、200、300、400、500和600Pa时的虹膜膨隆变形曲线。结论随着前后房压强差的增大,虹膜膨隆变形曲线的弯曲程度增大,该实验系统和方法可以获得虹膜膨隆变形与前后房压强差之间的规律。Objective To design an experimental system,which can simulate the pupil-blocking phenomena and passive deformation of iris tissue without destroying orbicular structure and activity of iris and to measure passive deformation of rabbit iris when difference between the pressure of anterior chamber and the pressure of posterior chamber changed. Methods The binocular stereo system,which was designed and improved upon the primary experimental device,can obtain continuous pressure data and corresponding 2D image of iris from two cameras in the course of load-pressure. The authors computed 3D coordinate of iris related to the difference of pressure based on stereo vision then dealt with the coordinate of Z axes,which was the height of passive deformation of iris,and obtained the curve of relation between the height of passive deformation of iris and the difference in pressure. Results The 3D data of iris during load-pressure was increased from 0 to 600 Pa. Sever curves of iris were 50 Pa,100 Pa,200 Pa,300 Pa,400 Pa,500 Pa and 600 Pa. Conclusion Passive deformation occurred in rabbit iris tissue when load-pressure was increased.

关 键 词：瞳孔阻滞 虹膜膨隆变形 立体视觉 闭角型青光眼 

分 类 号：R318.01[医药卫生—生物医学工程]