Smad2、Smad3和β-catenin在表达和意义病理性瘢痕中的  

Expression and significance of Smad2, Smad3 and β-catenin in pathological scar

作　　者：孙强[1] 郭澍[1] 唐明睿[1] 王晨超[1] 

机构地区：[1]中国医科大学附属第一医院整形外科,辽宁沈阳110001

出　　处：《中国美容整形外科杂志》2009年第12期754-757,共4页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：目的研究Smad2、Smad3和β-catenin在病理性瘢痕中的表达，探讨TGF-β／Smad信号传导通路和Wnt／β-catenin信号传导通路在病理性瘢痕发病机制中的作用及相互关系。方法应用免疫组化技术检测Smad2、Smad3和β-catenin在30例瘢痕疙瘩（A组）、30例增生性瘢痕（B组）及20例正常皮肤（C组）中的表达，并进行统计学分析。结果Smad2、Smad3在A、B组中的阳性率高于C组，但其差异无统计学意义（P〉0．05），但在核内积聚较C组明显，且其差异有统计学意义（P〈0．05）。13-eate．nin在A、B组中的表达与C组比较，其差异有统计学意义（P〈0．01），但A、B组之间的差异无统计学意义（P〉0．05）。结论TGF-β／Smad信号传导通路与Wnt／β-catenin信号传导通路联合作用，导致病理性瘢痕形成。Objective To investigate the expression of Smad2, Smad3 and β-catenin in pathological scar and to explore the role and relation of TGF-β/Smad signal pathway and Wnt/β-catenin pathway in the pathogenesis of pathological scar. Methods Immunohistochemiscal techuique （IHC） was performed to detect the expression and distribution of Smad2, Smad3 and β-catenin in 30 cases of keloid （group A） , 30 cases of hypertrophic scar （ group B） and 20 cases of normal skin （ group C）, and statistics was used to analyze the data. Results The positive rates of Smad2, Smad3 in group A and B were not distinct from that in group C （P 〉 0.05 ）, but the intranuclear accumulations were obvious （ P 〈 0. 05 ）. Compared group A and B with group C, there was significant difference in the expression of β-catenin （ P 〈 0.01 ）, but their expressions were not statistically different between group A and group B （ P 〉 0. 05 ）. Conclusion The cooperation of TGF-β/Smad signal pathway and Wnt/β-catenin signal pathway causes the formation of pathological scar.

关 键 词：SMAD2 SMAD3 β—catenin 病理性瘢痕 

分 类 号：R619.6[医药卫生—外科学]