预注氟比洛芬酯对丙泊酚实施人流手术麻醉效果的影响  

ANALYSIS ON THE EFFECT OF FLURBIPROFEN AXETIL PRE-PERFUSION ON ANESTHESIA WITH PROPOFOL IN ARTIFICIAL ABORTION OPERATION

作　　者：徐洪刚[1] 王昊[1] 王秀梅[1] 

机构地区：[1]辽宁医学院附属第一医院麻醉科,锦州121001

出　　处：《现代预防医学》2010年第1期188-189,192,共3页Modern Preventive Medicine

摘　　要：[目的]探讨预注氟比洛芬酯脂微球注射液对丙泊酚实施人流手术麻醉效果的影响。[方法]将160例ASAⅠ～Ⅱ级行人流手术患者随机双盲均分为两组,每组80例:A组,麻醉诱导前静脉注射脂肪乳安慰剂10ml;B组,麻醉诱导前静脉注射氟比洛芬酯注射液10ml。丙泊酚实施麻醉诱导,记录术中镇痛效果和术后宫缩痛的情况;同时连续监测入室后(T0)、麻醉诱导后(T1)、术中(T2)、术毕(T3)的平均动脉压(MAP)和心率(HR);观察记录两组患者丙泊酚的用量、麻醉恢复时间及术中、术后不良反应的发生情况。[结果]在T3点与B组比较,A组的MAP明显升高、HR明显加快(P﹤0.05);B组术中镇痛情况明显优于A组,术后宫缩痛也明显轻于A组(P﹤0.05);B组术中丙泊酚追加量和总用量,与A组相比明显减少(P﹤0.05);两组术后恶心呕吐、头晕头痛发生率的差异无统计学意义。[结论]氟比洛芬酯脂微球注射液能有效减少丙泊酚用量,加强术中镇痛效果,明显减轻术后宫缩痛,不增加麻醉恢复时间,不良反应低。[Objective] To evaluate the effect of flurbiprofen axetil preperfusion on anesthesia with propofol in artificial abortion operation. [Methods] In the double blind study,160 ASAⅠ～Ⅱ patients undergoing artificial abortion operation were equally randomized to two groups with 80 patients in each group. In group A,the patients were preperfused with 10ml fat emulsion placebo before anesthesia induction,while in group B the patients preperfused with 10ml flurbiprofen axetil. Propofol was used for anesthesia induction in both groups. The analgesia and postoperation uterine contraction pain were recorded and mean arterial pressure （MAP）,heart rate in the time points of T0,T2,T3,T3 were monitored. Total dose of propofol,anesthestic recovery time and the adverse reaction were compared between two groups. [Results] At time T3,MAP and HR were higher in group A compared with those in group B （P﹤ 0.05）. The effect of analgesia during operation in group B was superior than group A. Post-operation uterine contraction pain in group B was less than that of group A. Average dose of propofol in group B was less than that in group A. The adverse reactions including vomiting and headache between two groups were not significantly different. [Conclusion] The injection of flurbiprofen axetil can reduce the amount of propofol needed in the operation,strengthen the effect of analgesia and reduce uterine contraction pain without the increase anesthetic recovery time and adverse reactions.

关 键 词：氟比洛芬酯 丙泊酚 无痛人流术 

分 类 号：R614[医药卫生—麻醉学]