72例环孢素A所致不良反应文献分析  

Literature Analysis of ADRs Caused by Cyclosporine A

作　　者：程凯[1] 贾萍[2] 徐珽[3] 唐尧[3] 胡海波[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]四川省妇幼保健院,四川成都610013 [3]四川大学华西医院,四川成都610041

出　　处：《中国药业》2010年第1期36-37,共2页China Pharmaceuticals

摘　　要：目的分析环抱素A(CoA)所致药品不良反应(ADR)的临床特征、相关因素和防治对策,供临床参考。方法检索1980年至2008年国内医学期刊报道的CsA所致ADR病例并进行统计和分析结果检索到CsA所致ADR 72例,男性多于女性:多发生于泌尿、消化、神经系统计及牙龈.一般较严重.但及时处理预后较该。结论器官移植后.伸用CsA应定期检测血药浓度,注意可能出现的ADR。Objective To analyse the clinical features, correlation factors, preventions and cures of ADRs caused by cyclosporine A （CsA） and to provide beneficial references for preventing and curing ADRs. Methods To collect and analyse the cases of ADRs caused by CsA from the medical journals of 1980-2008. Results Totaly, 72 ADRs by CsA were reported. The incidence of male subjects seemed higher than that of the female subjects. Most of ADRs occurred in urinary, gastroinestinal, nervous system and gingiva. ADRs were usually severe with good prognosis. Conclusion Monitoring plasma concentration and more attention should be given to the patients with CsA after organ transplantation.

关 键 词：环抱素A 药品不良反应 文献分析 

分 类 号：R969.3[医药卫生—药理学] R979.5[医药卫生—药学]