宫颈病变早期筛查方法的新进展  

New development of cervical disease early screening

作　　者：李亚波[1] 杨红英[2] 

机构地区：[1]云南省中医医院检验科,昆明市650021 [2]昆明医学院第二附属医院检验科,昆明650000

出　　处：《生殖医学杂志》2009年第6期577-581,共5页Journal of Reproductive Medicine

摘　　要：宫颈癌是严重威胁妇女健康的恶性肿瘤之一,有效的筛查和早期诊断方法可大大降低其发病率和死亡率。目前国内外常用的早期实验室诊断,包括宫颈细胞涂片形态检测、人乳头瘤病毒(HPV)检测、分子细胞遗传学检测等。本文重点介绍荧光原位杂交(FISH)技术检测子宫颈上皮脱落细胞人端粒酶基因(TERC gene)的异常表达在宫颈癌早期诊断中的进展。Cervical cancer is one of malignant tumors that seriously threaten womenrs health, effective screening and early diagnosis can greatly reduce the morbidity and mortality. At present, commonly used early screening methods domestically and abroad include： detection of cervical cells form smear, human papillomavirus testing, molecular cell genetics testing and so on. This article focuses on the new development of cervical disease early diagnosis of genomic expression of the human telomerase gene in cytological specimens of the cervix by fluorescence in situ hybridization.

关 键 词：早期诊断 颈椎病 筛查 分子细胞遗传学 荧光原位杂交 病毒检测 恶性肿瘤 早期检查 

分 类 号：Q343[生物学—遗传学] S858.23[农业科学—临床兽医学]