类风湿关节炎的血小板计数与血清血小板生成素的相关性研究  

Relationship between Platelets and Serum Thrombopoietin in Rheumatoid Arthritis

作　　者：刘永玉[1] 巩路[1] 周蕾[1] 陈且峰[1] 

机构地区：[1]天津医科大学总医院感染免疫科,300052

出　　处：《天津医药》2009年第12期1023-1025,共3页Tianjin Medical Journal

摘　　要：目的:探讨血小板生成素(TPO)在类风湿关节炎(RA)患者血小板增多发生机制中的作用。方法:选取伴血小板增多RA患者29例、血小板正常RA患者28例及正常对照28例,采用酶联免疫吸附法(ELISA)检测血清TPO及白细胞介素-6(IL-6)水平,并与实验室参数进行相关性分析。结果:(1)伴血小板增多RA组血清TPO、IL-6水平均明显高于正常对照组(P<0.05或P<0.01);伴血小板增多RA组的TPO水平高于血小板正常RA组(P<0.05),而2组间IL-6水平差异无统计学意义(P>0.05)。(2)伴血小板增多RA组血小板计数与血清TPO水平之间无相关性,而与血清IL-6、CRP呈正相关(r分别为0.566,0.401,P<0.05或P<0.01)。(3)伴血小板增多RA组血清TPO水平与IL-6水平无相关关系(r=-0.069,P>0.05)。结论:(1)伴血小板增多RA组血清TPO水平显著升高,提示TPO参与了RA患者血小板增多的发生机制。(2)RA患者血小板增多与体内炎症反应有关。Objective： To investigate the relationship between platelets and serum thrombopoietin （TPO） in rheumatoid arthritis （RA） and the mechanism of RA with thrombocytosis thereof. Methods： The clinical data of 57 patients with RA were analyzed. Patients were divided into two groups by platelet count： high platelet count （300×109/L） and normal platelet count. There were 28 healthy persons as control. Serum levels of TPO and interleukin （IL）-6 were measured using enzyme-linked im- munosorbent assay（ELISA） in patients with RA and healthy controls. Results：（1）Serum TPO and IL-6 were higher in RA with thrombocytosis than those of healthy controls （P 0.05）. Compared the two RA groups, the one with thrombocytosis had higher serum TPO（P 0.05）. （2）The platelet count of RA with thrombocytosis did not correlate with serum level of TPO. It correlated significantly with serum level of IL-6 （r = 0.566, P 0.01） and C-reactive protein （CRP） （r = 0.401, P 0.05）. （3）The serum level of TPO in RA with thrombocytosis did not correlate with serum IL-6 （r = -0.069, P 0.05）. Conclusion： The serum level of TPO was significantly elevated in RA with thrombocytosis, which suggested that TPO may take part in the pathology of thrombocytosis in RA. The thrombocytosis in RA correlated with inflammatory reaction.

关 键 词：关节炎 类风湿 血小板增多 血小板生成素 白细胞介素6 

分 类 号：R581.1[医药卫生—内分泌] R973[医药卫生—内科学]