HSP70在青壮年猝死综合征心肌组织中的变化  

The variance of HSP70 in cardiac cells of SMDS victims

作　　者：闫记全 竞花兰[2] 张宜骏 徐宏泉 温涌溪 林泓 姜富学[4] 鲁天瑜[2] 

机构地区：[1]深圳市人民检察院技术处,广东深圳518023 [2]中山大学中山医学院法医学系,广东广州510080 [3]广州市人民检察院技术处,广东广州510000 [4]广州市公安局刑科所,广东广州510000

出　　处：《中国法医学杂志》2009年第6期394-396,I0010,共4页Chinese Journal of Forensic Medicine

基　　金：深圳市科技局科研项目(2002-K3-117)

摘　　要：目的探讨热休克蛋白70(HSP70)在青壮年猝死综合征形成机制中的作用,及其早期诊断作用。方法取30例青壮年猝死、20例正常对照心脏标本的左右心室肌、窦房结、房室结组织,通过免疫组化学染色,应用图像分析软件对HSP70分布及强度变化进行定量检测分析,并进行统计学处理。结果青壮年猝死者心肌传导系统内HSP70表达高于正常对照组,且具有统计学意义(P<0.05)。其中青壮年猝死者右心室肌HSP70的表达显著低于其他部位心肌组织(P<0.05)。结论HSP70作为一种应激反应的介质参与青壮年猝死综合征的发生过程,并对心脏起到保护性作用。HSP70可作为青壮年猝死综合征诊断的参考指标。Objective This article aims to explore the role of HSP70 in the developing mechanism of SMDS sudden manhood death syndrome, SMDS） and to investigate the value of it in the early diagnosis of SMDS. Methods By way of immunohistochemical staining of left, right ventricular tousles, sino atrial node and atrioventricular node from 30 cases of SMDS group and 20 cases of control group, we observed and measured the expression of HSP70 and its variance of intensity with graphical analysis software. Results Compared with the control group cases, in cardiac conduction system tissue of SMDS victims, we saw an obviously higher expression and intensity of HSP70 （P 〈 0.05）. Conclusion As a kind of mediator in stress reaction, HSP70 is involved in the process of protecting the heart from impairment in SMDS, and it can be considerated as a reference index to identify the SMDS.

关 键 词：法医病理学 热休克蛋白70 青壮年猝死综合征 免疫组化 

分 类 号：D919[医药卫生—法医学]