原发性干燥综合征患者并发社区获得性肺炎的危险因素分析  

Analysis of the risk factors of community-acquired pneumonia in patients with primary Sjgren's syndrome

作　　者：赵毅[1] 刘艺[1] 谭淳予[1] 陈征[2] 余克强[3] 

机构地区：[1]四川大学华西医院风湿免疫科,四川成都610041 [2]南方医科大学公共卫生与热带医学学院生物统计学系,广东广州510515 [3]南方医科大学科技处,广东广州510515

出　　处：《南方医科大学学报》2009年第12期2418-2420,共3页Journal of Southern Medical University

基　　金：国家自然科学基金(30400614)

摘　　要：目的回顾性研究原发性干燥综合征患者并发社区获得性肺炎的危险因素。方法选取2003年1月至2007年12月在四川大学华西医院风湿免疫科住院治疗的原发性干燥综合征患者,对多项观察指标进行单因素分析和logistic回归分析。结果121例原发干燥综合征患者中有27.3%合并社区获得性肺炎。单因素分析显示年龄、病程、白细胞降低、补体降低、肝功异常、肾功异常、白蛋白降低、高球蛋白、肾小管酸中毒、间质性肺病和免疫抑制剂与原发性干燥综合征合并社区获得性肺炎相关。Logistic回归显示肺间质改变(P=0.022,OR=6.300)、补体降低(P=0.019,OR=5.219),高球蛋白(P=0.021,OR=6.649)是原发性干燥综合征合并社区获得性肺炎的危险因素。结论积极控制原发性干燥综合征的疾病活动,减少危险因素的发生可能是控制原发性干燥综合征合并肺部感染的有效手段。Objective To investigate the risk factors of community-acquired pneumonia （CAP） in patients with primary Sj觟gren＇s syndrome （pSS）. Methods The clinical data were collected from 121 inpatients with pSS and univariate analysis and logistic regression were conducted to analyze the risk factors of CAP. Results The incidence of CAP in the 121 patients with pSS was 27.3%. Age, disease course, low while blood cells, low complement levels, liver and kidney dysfunction, low albumin, hyperglobulinaemia, renal tubule acidosis, interstitial lung disease （ILD） and immunosuppressive agents were closely related to CAP in these patients. Logistic regression analysis identified ILD, low complement levels and hyperglobulinemia as the risk factors for CAP in patients with pSS. Conclusion Vigorous control of pSS and minimizing the risk factors may prove effective to lower the incidence of CAP in patients with pSS.

关 键 词：干燥综合征 社区获得性肺炎 危险因素 

分 类 号：R593.2[医药卫生—内科学]