AIDS的免疫重建和免疫治疗  

Immune reconstitution and immunotherapy for AIDS

作　　者：张政 王福生 

机构地区：[1]解放军传染病研究所,北京100039

出　　处：《传染病信息》2009年第6期325-329,共5页Infectious Disease Information

基　　金：国家杰出青年科学基金(30525042)

摘　　要：HIV-1慢性感染主要破坏人体免疫系统。虽然高效抗逆转录病毒治疗能够通过抑制病毒复制在部分患者中实现免疫重建,但由于其本身局限性,很难清除体内HIV-1储藏库。近年来,一些新的免疫治疗策略和手段纷纷涌现,其最终目标是实现免疫重建。本文针对AIDS的免疫重建和免疫治疗作一综述。Chronic HIV-1 infection mainly destroys the immune system in humans. Although highly active antiretreviral therapy can reconstitute the host immunity in some treated patients by inhibiting the viral replication, it hardly clears in vivo viral reservoir due to its limitations. Recently, some new therapeutic strategies and measures have occurred, which finally aim at the immune reconstitution of chronically HIV-1-infected patients. This article reviews the immune reconstitution and immunotherapy for AIDS.

关 键 词：HIV 免疫重建 免疫治疗 

分 类 号：R512.91[医药卫生—内科学]