香丹注射液治疗急性重型颅脑损伤的内皮素含量与临床疗效观察  

Clinical application of Salvia in the treatment of acute severe brain injury

作　　者：薛洪利[1] 张国华[1] 于春泳[1] 吕占举[1] 周江朝[1] 邵双伟[1] 

机构地区：[1]沈阳军区总医院神经外科,辽宁沈阳110016

出　　处：《国际神经病学神经外科学杂志》2009年第6期492-494,共3页Journal of International Neurology and Neurosurgery

摘　　要：目的观察丹参治疗急性重型颅脑损伤后的血浆内皮素(ET)含量变化与临床疗效的关系。方法按标准选取急性重型颅脑损伤病人30例,随机分成对照组和试验组。对照组行常规治疗,试验组在常规治疗基础上加用香丹注射液治疗。治疗前和治疗后24小时、48小时、72小时、1周及2周分别采取肱静脉血,采用非平衡法测血浆内皮素含量,检测试验组病人的血压,治疗后1、3、7天两组病人行CT检查。两组病人分别于治疗前和治疗后3天、1周分别行格拉斯哥昏迷评分(GCS),比较两组的疗效。结果治疗后试验组血浆ET含量明显低于对照组,GCS高于对照组,差异均有统计学意义(P<0.05),治疗前后血压变化不明显(P>0.05),两组病人头CT均未见脑出血增加。结论丹参对急性重型颅脑损伤病人具有明显的临床治疗效果。Objective To observe the change of endothelin （ET） and the clinical efficacy of Xiangdan Injection in the treatment of acute severe brain injury. Methods In accordance with the selected criteria, 30 patients with acute severe brain injury were randomly divided into control group （n = 15 ）, experimental group （n = 15 ）. The control group was given conventional treatment, the experimental group was given Xiangdan injection on the basis of conventional treatment. Before treatment and after treatment for 1 ＇ d, 2＇ d, 3＇ d, 1 ＇ week and 2＇ weeks, endothelin （ET） content of blood plasma from brachial vein and blood pressure of the experimental group＇ s patient were measured, after treatment for 1 ＇ d, 3＇ d, 1 ＇ week, head CT of two group＇ s patient were carried out. Before treatment and after treatment for 3＇ d and 1 ＇ week, Glasgow coma scale （ GCS ） for each patient were evaluated for compared the efficacy of the two groups of patients. Results The plasma endothelin （ET） significantly decreased and Glasgow coma scale （ GCS ） significantly increased in experimental group after treatment compare to experimental group（ P 〈 0.05 ）. The blood pressure change smaller in all group （ P 〉 0.05 ）. In both groups of patients, cerebral hemorrhage wasn＇ t increased from CT. Conclusions Salvia has the obviously clinical efficacy for acute severe brain injury.

关 键 词：香丹注射液 颅脑损伤 内皮素 

分 类 号：R269[医药卫生—中西医结合]