大鼠PAG内微量注射神经降压素增强β-内啡肽的镇痛作用  

NEUROTENSIN INJECTED INTOPERIAQUEDUCTAL GRAY COULD HEIGHTEN EFFECTOF β-ENDORPHIN ANALGESIA IN RAT

作　　者：葛凤[1] 刘文彦[1] 刘玉红[1] 王曙光[1] 邱翠娥[1] 

机构地区：[1]济宁医学院神经生理研究室

出　　处：《济宁医学院学报》1998年第3期11-13,共3页Journal of Jining Medical University

摘　　要：目的探讨大鼠中脑导水管周围灰质内神经降压素和β－内啡肽对痛阈的影响。方法本工作以钾离子透入法引起大鼠甩尾反应的电流强度（ｍＡ）为痛反应指标，观察了大鼠中脑导水管周围灰质内注入β－内啡肽、抗β－内啡肽血清和神经降压素对大鼠痛阈的影响。结果中脑导水管周围灰质内注入β－内啡肽后，大鼠痛阈明显升高；注入抗β－内啡肽血清后，大鼠痛阈则明显降低。中脑导水管周围灰质内注入微量神经降压素后，可明显加强β－内啡肽的镇痛效应。结论ＮＴ参与中脑导水管周围灰质内注射β－内啡肽引起的镇痛效应。]Objective The effect of neurotensin (NT),anti-β-endorphin serum(AEPS) andβ-endorphin (β-EP) injected into periaqueductal gray (PAG) on the pain threshold in rats was investigated in this study.Methods The potassium iontophoresis induced tail-flick was used to measure the pain threshold.Results β-EP which was injected into PAG produced analgesia effect in the rat.AEPS could weaken the pain threshold in PAG of rats.The micioinjection of NT in PAG could heighten effect of β-EP analgesia. Conclusion Our results indicated that β-EP could enhance the analgesia effect in PAG of rats,and this action of β-EP had closely related with the NTin PAG. 

关 键 词：神经降压素 Β-内啡肽 导水管周围灰质 痛阈 

分 类 号：R614[医药卫生—麻醉学]