人参皂苷Rh_2与顺铂对荷S_(180)小鼠抗肿瘤作用实验研究  

Antitumor Effect of Ginsenoside Rh_2 Combining with DDP on S_(180) Bearing in Mice

作　　者：樊锦坤 王嘉怡[2,3] 卿晨[2] 

机构地区：[1]广州市番禺区石碁人民医院,广州511450 [2]昆明医学院云南省天然药物药理重点实验室 [3]广州市儿童医院

出　　处：《中国药师》2010年第1期15-17,共3页China Pharmacist

摘　　要：目的:研究人参皂苷Rh_2与化疗药顺铂(DDP)联合应用,在小鼠肉瘤180(S_(180))的实验性治疗中的作用,为临床治疗中的合理联用提供参考依据。方法:以小鼠S_(180)为模型,采用正交设计方法进行实验,确定Rh_2和DDP联合应用于小鼠S_(180)的实验性治疗中,两者之间是否存在交互作用、以及交互作用的性质,并通过析因设计方法进行进一步的验证。结果:正交实验结果显示,Rh_2与DDP联用时存在交互作用,表现为协同作用;进一步的析因实验验证,一定剂量的Rh_2(0.5 mg·kg(-1))与DDP(0.2 mg·kg^(-1))联用时,存在协同作用。结论:Rh_2与DDP联合应用时,增强DDP的抗肿瘤作用,两药联用时表现出良好的抗肿瘤作用。Objective： To investigates the cross effect between ginsenoside Rh2 and therapeutic drug cisplatin （DDP） on the sarcoma 180 （S180 ） bearing in mice treated by ginsenoside Rh2 combining with DDP. Method： The antitumor effect of ginsenoside Rh2 combining DDP on the sarcoma 180 bearing in mice was evaluated by tumor weight. The cross effect between ginsenoside Rh2 and DDP on growth of S180 was identified by using orthogonal design experiment and the result was further proven by factorial design experiment. Result： The cross effect was found in experimental antitumor treatment, and the cross effect was exhibited synergetie. Conclusion： Gin- senoside Rh2 is able to enhance the experimental chemotherapeutical effect of DDP when the combination of both.

关 键 词：人参皂苷RH2 顺铂 肿瘤 

分 类 号：R73-354[医药卫生—肿瘤]