心肌梗死再灌注治疗药物使用的性别差异研究  

Effect of Sex on Reperfusion Therapy and Cardiovascular Drugs Utilization After Myocardial Infarction with ST-Segment Elevation

作　　者：付文强[1] 

机构地区：[1]天津市胸科医院,天津300051

出　　处：《中国药师》2010年第1期103-104,共2页China Pharmacist

摘　　要：目的:研究ST-段抬高心肌梗死再灌注治疗和心血管药物使用的性别差异。方法:选取2006年6月～2008年7月我院确诊为ST-段抬高心肌梗死患者病例400份分为男性和女性组,比较两组患者入院时合并疾病、心肌梗死部位、住院期间新发合并症以及再灌注治疗和心血管用药情况。结果:有男性患者292人,平均年龄64岁;女性108人,平均年龄69岁。男女患者接受冠脉血管重建术、溶栓、抗血小板和抗凝药物、β-受体阻断药、ACEI或ARB、他汀类药物、硝酸酯类、利尿药和钙通道阻断剂人数(比例)分别为:274(93.8%)与98(90.7%);12(4.1%)与6(5.6%);292(100%)与108(100%);266(91.1%)与92(85.2%);244(83.6%)与84(77.6%);256(87.7%)与87(80.6%);188(64.4%)与72(66.1%);194(66.4%)与74(68.5%)和52(17.8%)与24(22.2%),均无统计学差异。结论:急性ST-段抬高心肌梗死再灌注治疗和心血管药物利用上没有性别差异。Objective： To determine the effect of sex on repeffusion therapy and cardiovascular drugs utilization after myocardial infarction with ST-segment elevation （STEMI）. Method： Data collection began in June 2006 and continued until July 2008,400 patients with STEMI were enrolled into the study. The characteristics, use of reperfusion therapy and cardiovascular drugs in hospitals between female and male patients with STEMI were compared. Result： The patients of 292 men, mean age 64 years, and 108 women, mean age 69 years ,with STEMI. Coronary revascularization therapy were given to 274 men （93.8%） and 98 women （90.7%） （P = not significant （NS） ]. Thrombolytic therapy was given to 12 men （4.1%） and 6 women （5.6%） （P = （NS）. Antiplatelet therapy and antithrombotic therapy were given to 292 men （ 100% ） and 108 women （ 100% ） （ P = NS）. Beta-blockers were given to 266 men （91.1% ） and 92 women （85.2%） （P = NS）. Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were given to 244 men （83.6%） and 84 women （77.6%） （P = NS）. Statins were given to 256 men （87.7%） and 87 women （80.6%） （P = NS）. Nitrates were given to 188 men （64.4%） and 72 women （66.1% ） （P = NS）. Diuretics were given to 194 men （66.4%） and 74 women （68.5%） （P = NS）. Calcium channel blockers were given to 52 men （ 17.8% ） and 24 women （22.2%） （P = NS）. Con- clusion： There were no statistical difference in the treatment of men versus women with acute STEMI.

关 键 词：心肌梗死 急性 再灌注治疗 抗血小板治疗 Β-受体阻断药 他汀类药物 

分 类 号：R541.4[医药卫生—心血管疾病]