射频心外膜消融Marshall韧带治疗房颤动物实验研究  

作　　者：徐长芬[1] 雷森[1] 鲁跃华[1] 

机构地区：[1]成都医学院附属第二医院（成都铁路中心医院）心内科,610081

出　　处：《浙江临床医学》2009年第11期1123-1125,共3页Zhejiang Clinical Medical Journal

摘　　要：目的研究射频心外膜消融Marshall韧带治疗房颤的效果。方法将20只犬随机分为消融组及对照组，各10只，于心外膜Marshall韧带注射肾上腺素＋短阵快速刺激诱发房颤，消融组以心外膜射频消融，对照组假消融。分别于建立房颤模型前后及消融或假消融后测定左上下肺静脉及左心耳不应期和房颤诱发率。术毕行组织学检查。结果消融组、对照组组内房颤模型建立前后房颤诱发率比较差异均有统计学意义（P〈0．05）；消融或假消融后，消融组房颤诱发率降低（P〈0．05），对照组房颤诱发率无明显变化（P〉0．05）。消融组房颤模型建立前后及消融后左肺静脉不应期无明显变化（P〉0．05），对照组房颤模型建立前后不应期变化差异有统计学意义（P〈0．05）。消融组组织学检查示射频消融后Marshall韧带组织凝固性坏死。结论射频消融Marshall韧带治疗房颤有效。Objective To study the feasibility of the radiofrequency ablation of the ligament of Marshall in treatment of atrial fibrillation. Methods 20 mongrel dogs were randomly divided into ablation group and control group （10 dogs in each group）. Adrenine injection and Burst stimulation were used to induce atrial fibrillation. Radiofrequency was delivered to ablate ligament of Marshall. Atrial fibrillation inducibility and effective refractory period of left pulmonary veins and left atrium were measured in the study. Results Inducibility of atrial fibrillation was significantly increased after adrenine injection （ P 〈 0. 05 ） and significantly decreased after ablation of ligament of Marshall （ P 〈 0. 05 ）. There was no significant difference in effective refractory period in ablation group（ P 〉 0. 05 ） ; In control group, the significant difference of effective refractor perild was found （ P 〈 0. 05 ） before adrenine injection and after adrenine injection（P 〈 0. 05 ）. Coagulation necrosis of LOM was presented after LOM ablation in ablation group. Conclusion Radiofrequeney ablation in ligament of Marshall is effective for treating atrial fibrillation.

关 键 词：心房颤动 射频消融 MARSHALL韧带 

分 类 号：R541.75[医药卫生—心血管疾病] R541.750.5[医药卫生—内科学]