环境铅暴露对大鼠海马CA_1区长时程增强的影响  

Effects of Environmental Exposure to Lead on in Vivo Induction of Longterm Potentiation in Rat Hippocampal CA 1 Area

作　　者：刘君澜[1,2] 时利德[1,2] 李北利[1,2] 万伯健 

机构地区：[1]中国医科大学卫生毒理学教研室 [2]中国医科大学脑研究所神经生理室

出　　处：《中国公共卫生学报》1998年第4期221-223,共3页

基　　金：自然科学基金

摘　　要：用神经生理细胞外玻璃微电极记录方法，观察环境铅暴露对年幼大鼠海马ＣＡ１区ＬＴＰ的影响。结果：铅暴露组与对照组比较，ＰＴＰ的平均群体峰电位振幅增强率无差别；ＬＴＰ发生率与平均ＰＳ电位振幅增强率显著降低。ＰＳ电位增强率与脑铅浓度呈显著负相关。? This study with the method of extracellular glass microelectrode recording of neurophysiology,examined the effects of enviromental exposure to lead on young rats' LTP of hippocampal CA 1 areas.in contrast,no significant changes were found in popula tion spike amplitudes of PTP of Pbexposed rats;The incidences of LTP and average population spike amplitudes increase percent were markedy decreased.Population spike potentiation increase rate is markedy correlated with brain lead concentration in negative direction.It suggested environmental exposure to lead impaired LTP,induction and maintain of hippocampal CA 1 area of young rats.

关 键 词：铅暴露 海马 长时程增强 毒理 

分 类 号：R994.6[医药卫生—毒理学]