镉对大鼠肝微粒体膜的毒性作用及维生素C的拮抗效应  

Effects of Cadmium Chloride on Membrane Toxicity of Rat Liver Microsomes and Vitamin C Antagonistic action

作　　者：叶建锋[1] 高宁[1] 卓鉴波[2] 

机构地区：[1]第一军医大学毒理学教研室 [2]第三军医大学军队教研室

出　　处：《中国公共卫生学报》1998年第4期226-228,共3页

摘　　要：采用荧光偏振等技术方法，体外观察ＣｄＣｌ２对大鼠肝微粒体膜流动性，膜脂质过氧化物丙二醛（ＭＤＡ）生成的毒性作用和维生素Ｃ的拮抗作用。结果表明，ＣｄＣｌ２可在较短时间内引起膜流动性的降低和ＭＤＡ的增高；维生素Ｃ处理不能改善ＣｄＣｌ２引起的微粒体膜流动性的降低，但能完全拮抗ＭＤＡ的增高。结果提示。? The effects of Cd^2+ on rat hepatic and microsome membrane fluidity,membrane lipid peroxidate malonyldialdehyde(MDA)and vitamin C antagonistic effect were investigated.The results showed that the fluorecence polarization of DPH labeled on the membrane microsome significantly increased.An increase in MDA of microsome due to Cd2+was also observed at final concentration 25 mmol·L-1 and 25μmol·L-1.Increased MDA and decreased fluidity of membrane had good correlation and they all happened in a very short time.Vitamin C treatment had no effect on the fluidity of microsomal membrane,but completely antagonised the increase of MDA.

关 键 词：氧化镉 膜脂质流动性 膜脂质过氧化 维生素C 

分 类 号：R995[医药卫生—毒理学] R992[医药卫生—药学]