子午流注针法对减少慢性乙型肝炎HBV-YMDD变异的临床观察  

Clinical Observations on Reducing Effect of Midnight-midday ebb flow Acupuncture on Chronic Hepatitis B HBV-YMDD Mutation

作　　者：邵志林[1] 费新应[1] 陈炎生[1] 沈震[1] 张炳煌[2] 

机构地区：[1]黄石市中医院肝病科,湖北435000 [2]湖北中医学院,2007级硕士班武汉430061

出　　处：《上海针灸杂志》2009年第12期694-695,共2页Shanghai Journal of Acupuncture and Moxibustion

摘　　要：目的观察运用子午流注针法对减少乙型肝炎病毒YMDD变异的临床疗效。方法将220例慢性乙型肝炎患者随机分为对照组88例,治疗组132例,分别给予拉米夫定口服,治疗组在此基础上加用子午流注针法联合治疗24个月,分阶段观察患者ALT复常率、HBeAg阴转率、HBV-DNA阴转率,及治疗12个月、18个月、24个月的YMDD变异率。结果治疗组较对照组在ALT复常率、HBV-DNA阴转率、HBeAg阴转率、治疗24个月时YMDD变异率方面均明显优于对照组(P<0.05)。结论运用子午流注针法联合拉米夫定治疗慢性乙型肝炎,对改善患者肝功能,提高拉米夫定抑制病毒复制具有良好的作用,并可减少病毒YMDD变异。Objective To investigate the clinical reducing effect of midnight-midday ebb flow Acupuncture on HBV-YMDD mutation. Methods Two hundred and twenty patients were randomly allocated to a control group of 88 cases and a treatment group of 132 cases. Both groups took Lamivudine orally. In addition, the treatment group received midnight-midday ebb flow acupuncture for 24 months. In the patients, the ALT normalization rate, HbeAg negative conversion rate and HBV-DNA negative conversion rate were examined after different periods of treatment respectively and the YMDD mutation rate, after 12, 18 and 24 months of treatment. Results The ALT normalization rate, HbeAg negative conversion rate, HBV-DNA negative conversion rate and after-24 month treatment YDMM mutation rate were all significantly better in the treatment group than in the control group （P〈0.05）. Conclusion The combined treatment of chronic hepatitis B with midnight-midday ebb flow acupuncture and Lamivudine plays a good role in improving the hepatic function of the patients and the inhibitory effect of Lamivudine on virus replication and can reduce viral YMDD mutation.

关 键 词：肝炎 乙型 针灸疗法 子午流注纳甲法 肝炎病毒 乙型 YMDD变异 

分 类 号：R246.1[医药卫生—针灸推拿学]