维生素A和亚硒酸钠对菜油烟冷凝物致小鼠毒性作用的影响  

EFFECT OF VITAMIN A AND SODIUM SELENITE ON RAPESEED OIL VAPOR CONDENSATE TOXICITY IN MICE

作　　者：周纯先[1] 王帮霞[1] 肖棣[1] 

机构地区：[1]蚌埠医学院卫生学教研室

出　　处：《癌变．畸变．突变》1998年第4期230-232,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：本文报道了维生素Ａ和亚硒酸钠对菜油烟冷凝物致小鼠毒性作用的影响。结果表明：①菜油烟冷凝物组小鼠的体重明显低于补充维生素Ａ组和亚硒酸钠组（Ｐ＜０．０１）；②菜油烟冷凝物组小鼠的心脏器系数高于补充维生素Ａ和亚硒酸钠组（Ｐ＜０．０５）；③补充维生素Ａ和亚硒酸钠后，可显著地降低菜油烟冷凝物所致的小鼠微核率和精子畸形率（Ｐ＜０．００１和Ｐ＜０．０１），而单纯菜油组则无致小鼠微核率和精子畸形率升高的作用（Ｐ＞０．０５）。The effect of vitamin A(Vit A) and sodium selenite(Na_2SeO_3) on rapeseed oil vapor condensate toxicity was studied in mice. The results are:①The body weight of rapeseed oil vapor condensate group mice was significantly lower than that of addition Vit A group and Na 2SeO 3 group (P<0.01);②The heart organ index of rapeseed oil vapor condensate group mice was higher than that of supplyment Vit A group and Na 2SeO 3 group (P<0.05); and ③The rate of micronuclei and of sperm aberrations of rapeseed oil vapor condensate group were obviously higher than that of plus Vit A group and Na 2SeO 3 group (P<0.001 and P<0.01), but rapeseed oil group mice was didn't (P>0.05).

关 键 词：维生素A 亚硒酸钠 菜油烟冷凝物 小鼠 毒性作用 

分 类 号：R994.4[医药卫生—毒理学] R114[医药卫生—药学]