福州市儿童乙肝流行病学调查  

Epidemiological Investigation on Children's Hepatitis B in Fuzhou

作　　者：纪惠玲[1] 徐珊 陈艳[1] 陈孟南[1] 姚栩[1] 郭燕[1] 陈志伟[1] 郑能雄[1] 

机构地区：[1]福州市疾病预防控制中心,福建350004 [2]福清出入境检验检疫局,福州350300

出　　处：《海峡预防医学杂志》2009年第6期18-19,共2页Strait Journal of Preventive Medicine

基　　金：福州市科技局资助项目(No.2003-27)

摘　　要：[目的]调查福州市儿童开展乙肝疫苗免疫后乙肝病毒（HBV）感染及免疫水平的现况,有针对性地对重点人群制定更加有效的乙肝免疫策略。[方法]采用分层整群随机抽样的方法采集血清标本,分别以ELISA和时间分辨荧光法检测乙肝“两对半”,用SPSS 11.0软件统计检测结果。[结果]福州市0-15周岁儿童乙肝表面抗原（HB-sAg）阳性率为3.6%,抗-HBs平均滴度为170.63 mIU/ml,抗体阳性率为66.4%。[结论]福州沿海地区儿童HBsAg阳性率（5.3%）显著高于内陆地区（2.6%）,5岁以下儿童抗原阳性率（1.9%）高于全国平均水平。[Objective] To investigate the infection rate and antibody level of hepatitis B of children in Fuzhou who injected hepatitis B vaccine for the disease effective control and prevention. [Methods] Serum samples were collected by randomly stratified and cluster sampling method and the infection rate and antibody level were detected by using ELISA and TRFIA method. The data were analyzed by SPSS 11 package, [Results] The positive rate of HBsAg aged 1 to 15 was 3.6 % ,average titers of HBsAb was 170.63 mlU/ml,and positive rate of antibody was 66.4%.[Conclusions] The positive rate of coastal area children in Fuzhou with HBsAg （5.3 %） was significantly higher than that of inland areas （2.6%） and the positive rate of children below 5 years old （1.9%） was higher than national level.

关 键 词：乙型肝炎 乙肝病毒 乙肝疫苗 疾病控制 

分 类 号：R512.601[医药卫生—内科学] R186[医药卫生—临床医学]