增效炔醚合成工艺的改进  

Improvement in Synthesis of Verbutin

作　　者：陈连清[1] 施超[1] 李群丽[1] 渠星宇[1] 

机构地区：[1]中南民族大学化学与材料科学学院催化材料科学湖北省暨国家民委-教育部共建重点实验室,武汉430074

出　　处：《中南民族大学学报（自然科学版）》2009年第4期18-22,27,共6页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：国家自然科学基金资助项目(20702064);中南民族大学自然科学基金资助项目(YZZ07007)

摘　　要：为优化增效炔醚M B-599的合成工艺,改进了合成路线.以邻苯二酚为原料,经甲基化、乙酰化、还原制得1-(3,4-二甲氧苯基)乙醇,并与丙炔醇缩合为炔醚,制备端炔格氏试剂,最后与碘甲烷反应制得目标化合物,其收率与反应成本得到了一定的改善,并找到了一条新的合成路线.To optimize the synthesis of verbutin,the follouing improved synthetic route has been applied：catechol was using as the starting materials,through methylation,acetylation,and reduction,1-（3,4-dimethoxy-benzol） ethanol was obtained,which was then condensed with propargyl alcohol,from which terminal alkynyl Grignard reagent was prepared.Finally reaction with iodomethane yielded the target compounds.The cost and yield of verbutin were improved and a novel synthetic route was demonstrated.

关 键 词：增效剂 增效炔醚 格氏试剂 合成路线 

分 类 号：TB383[一般工业技术—材料科学与工程]