低分子肝素对慢性阻塞性肺疾病及血液流变学的影响  

作　　者：贾坤林[1] 徐翠蓉[1] 邓刚[1] 钟晓莉[1] 王永芬[1] 刘炎银 

机构地区：[1]四川省简阳市人民医院呼吸内科,641400

出　　处：《浙江临床医学》2009年第12期1264-1266,共3页Zhejiang Clinical Medical Journal

摘　　要：目的探讨应用低分子肝素对慢性阻塞性肺疾病及血液流变学的影响。方法将162例慢性阻塞性肺疾病患者随机分为观察组（84例）和对照组（78例），162例患者均积极控制呼吸道感染、改善呼吸功能、纠正酸碱平衡及电解质紊乱、治疗并发症。观察组加用低分子肝素，每次使用4000U，隔日1次，皮下注射，总疗程20d。结果观察组总有效率为92．86％，对照组总有效率为74．36％，前者显著改善全血粘度和红细胞压积等血液流变学指标，两组差异有统计学意义（P〈0．05）。结论低分子肝素治疗慢性阻塞性肺疾病可改善血液循环障碍和心肺功能，纠正低氧血症。Objective To explore the curative effect of low molecular weight heparins treats COPD and influence on blood theology. Methods 162 patients with COPD were divided randomly into the intervention group（84 cases） and the control group（78 cases）, and all 162 patients had respiratory anti - inflammation, improved respiratory function, corrected acid - base and electrolyte disturbances, were treated the complication, the intervention group were then treated by the combination of low molecular weight heparins and 20 days as a course of treatment. Result The effective rate was 92. 86% in treatment group while 74. 36% in control group, the former could also markedly improve the blood theological indexes of whole blood mucosity and packed cell volume, The difference between two groups had statistical significance （ P 〈 0. 05 ）. Conclusion Low molecular weight heparins therapy for COPD is clinically recommended for improvement of dysaemia, cardiorespiratory function, and rectification of hyoxemia.

关 键 词：慢性阻塞性肺疾病 血液流变学 低分子肝素 

分 类 号：R563.05[医药卫生—呼吸系统] R541.405[医药卫生—内科学]