蜂毒对胶原诱导大鼠关节炎TNF-α、IL-1β、PGE_2的影响  

Effect of Bee Venom on TNF-α、IL-1β、PGE_2 in Rats with Collagen-induced Arthritis

作　　者：赵争敏[1] 薛鸾[2] 曹瑶[1] 

机构地区：[1]连云港市中医院,江苏连云港222004 [2]上海中医药大学附属岳阳医院,上海200437

出　　处：《河南中医》2009年第12期1169-1171,共3页Henan Traditional Chinese Medicine

基　　金：江苏省科技攻关项目(编号:BS2006526);连云港市卫生局资助项目(编号:06053)

摘　　要：目的:探讨蜂毒治疗类风湿性关节炎的作用机理。方法:采用Ⅱ型胶原诱导大鼠关节炎模型,造模成功后随机分为甲氨蝶呤组、蜂毒治疗组、生理盐水对照组,每组均为15只,观察治疗前后大鼠的关节肿胀指数、外周血IL-1β、TNF-α、PGE2的变化。结果:蜂毒治疗组和生理盐水组大鼠关节肿胀指数、外周血IL-1β、TNF-α、PGE2差异无统计学意义(P>0.05),甲氨蝶呤组和生理盐水组大鼠关节肿胀指数、外周血TNF-α、PGE2差异有统计学意义(P<0.05)。结论:小剂量蜂毒对胶原诱导大鼠关节炎IL-1β、TNF-α、PGE2无明显影响。Objective ： To explore the mechanism of bee venom m the treatment of rheumatoid arthritis. Methods ： Type Ⅱ collagen -induced arthritis model were randomly divided into methotrexate group, bee venom group, saline control group, 15 rats in each group. The changes of joint swelling index, blood IL - 1β, TNF - α, PGE2 were observed before and after treatment. Results： There was no significant difference （ P 〉 0.05 ） in the changes of joint swelling index, peripheral blood IL - 1β, TNF - α, PGE2 of bee venom group and saline control group. There was significant difference （ P 〈 0.05 ） in the changes of joint swelling index, peripheral blood IL - 1β, TNF - α, PGE2 of methotrexate group, saline control group. Conclusion ： Small dose of bee venom have no significant effect on IL -1β, TNF - α, PGE2 in rats with collagen - induced arthritis.

关 键 词：蜂毒注射液 类风湿性关节炎 关节肿胀指数 血清IL-1Β 血清TNF—α 血清PGE2 

分 类 号：R285.5[医药卫生—中药学]