二茂铁衍生物清除羟自由基的构效关系  

Ferrocene Derivates: Hydroxyl Radical Scavenging Activity and Structure-Activity Relationships

作　　者：邱潇[1] 詹冬梅[1] 周文涓[1] 赵红莉[1] 蓝闽波[1] 

机构地区：[1]华东理工大学分析测试中心,上海200237

出　　处：《华东理工大学学报（自然科学版）》2009年第6期878-881,共4页Journal of East China University of Science and Technology

基　　金：欧盟第六框架项目NACBO(500804);上海市科委纳米专项(0752nm025)

摘　　要：采用化学发光法检测并比较了10种二茂铁衍生物清除羟自由基(.OH)活性,用循环伏安法研究了其电化学性质,进而探讨了取代基结构与清除.OH活性间的关系。结果表明,取代基共轭效应、诱导效应和体积都对衍生物清除.OH活性有明显影响。含共轭或吸电子取代基二茂铁衍生物,半波电位(E1/2)较高,清除.OH活性较弱;而含给电子取代基的二茂铁衍生物,E1/2较低,清除.OH活性较强。The hydroxyl radical（·OH） scavenging activity of ten ferrocene derivates（FcDs） were evaluated by chemiluminescence assay.The electrochemical properties were studied by cyclic voltammetry method.In addition,the relationship between substituent structure and ·OH scavenging activity was discussed.The results indicated that the ·OH scavenging activity was influenced by the conjugative effect,conductive effect and volume of substituents.The FcDs with conjugative or electron-withdrawing substituents,have more positive E1/2 and weaker ·OH scavenging activity,while the FcDs with electron-donating substituents,have more negative E1/2 and stronger ·OH scavenging activity.

关 键 词：二茂铁衍生物 羟自由基 化学发光 循环伏安 构效关系 

分 类 号：O63[理学—高分子化学]