美白祛斑药物对强脉冲光作用下的鼠皮黑色素的影响  

Effect of Freckle Whitening Drugs on Mouse Melanin Irradiated by Intense Pulsed Light

作　　者：章小曼[1] 吴淑莲[1] 李晖[1] 

机构地区：[1]医学光电科学与技术教育部重点实验室福建省光子技术重点实验室,福建师范大学物理与光电信息科技学院,福建福州350007

出　　处：《激光生物学报》2009年第6期722-724,共3页Acta Laser Biology Sinica

基　　金：国家自然科学基金项目(60578056);教育部优秀青年教师资助计划项目(BD0050);福建省教育厅项目(JB07044)

摘　　要：观察美白祛斑药物对强脉冲光(intensive pulse light,IPL)作用下的鼠皮黑色素的影响,探讨IPL作用下,皮肤的黑色素的增生和美白药物之间的作用关系,以期探寻美白药物在减少光子嫩肤术并发症的作用机制。以小白鼠作为研究对象,用IPL在一定的波长及能量密度照射活体小鼠皮肤,在照射后15 min涂抹低浓度的维A酸霜,分别在照射后的4 h、5 d,用显微镜观察涂霜剂、没涂霜剂的皮肤黑色素及其周边组织的变化情况;在照射后的1 d用多光子显微镜观察涂霜剂、没涂霜剂皮肤组织的变化。讨论了美白祛斑药物在光子嫩肤过程中抑制黑色素生成的过程,为如何减少光子嫩肤术并发症提供参考和借鉴。The effects of freckle whitening drugs on mouse melanin irradiated by IPL were observed with the slices dyed by hematoxylin-eosin. With the IPL, the relation between the increase of melanin and the effect of freckle whitening drugs was discussed. The mechanism of freckle whitening drugs in reducing the complications in photo rejuvenation was expected to be found. Several groups were chosen and moulted, and then irradiated by the IPL system in vivo under certain wavelengths with certain energy densities. After 15 min, low concentrations of tretinoin ointment were smeared on the mouse skin. Then the morpholngic changes of the mouse skin were observed. The process of freckle whitening drugs inhibiting melanin in the photo rejuvenation was discussed.

关 键 词：IPL 黑色素 美白祛斑 维A酸 

分 类 号：R318.51[医药卫生—生物医学工程]