L-5-羟基色氨酸粉晶晶体结构解析  

Powder Crystal Structure Determination of L-5-HTP

作　　者：马红琼[1] 杨建华[1] 刘海峰[1] 承强[1] 李晖[1] 

机构地区：[1]四川大学化学工程学院,成都610065

出　　处：《化学通报》2009年第12期1104-1108,共5页Chemistry

基　　金：四川省科技攻关计划基金项目(05SG011-021-2)资助

摘　　要：以50%甲醇溶液为提取溶剂,从加纳籽中提取L-5-羟基色氨酸(HTP),采用RP-HPLC获得纯度为99.5%样品,经80%甲醇溶液重结晶获得多晶粉末。利用X射线粉末衍射技术结合计算晶体学方法解析其粉晶晶体结构,模拟图谱与实验图谱的Rwp值为5.06%。结果表明:该晶体属单斜晶系,P21空间群,晶胞参数为a=13.69927±0.01967,b=5.34550±0.00756,c=7.88219±0.01129,α=γ=90.00000°,β=86.25936±0.00359°,Z=2,V=579.973()3,并在此基础上对其晶体生长特性进行了分析。After extracting from G.simplicifolia seed by 50% methanol,pure L-5-HTP sample（99.5% by RP-HPLC） was obtained,then it was recrystallized in 80% methanol to get polycrystalline powder.Crystal structure of L-5-HTP was determined from its X-ray powder diffraction pattern through calculational crystallography methods with an Rwp of 5.06%.The results showed that the crystal structure of L-5-HTP is monoclinic,space group P2_1 with unit cell dimensions a=13.69927±0.01967？,b=5.34550±0.00756？,c=7.88219±0.01129？,α=γ=90.00000°,β=86.25936±0.00359°,Z=2,V=579.973（？）3.The crystal growth characteristics of L-5-HTP were analyzed based on the results.

关 键 词：L-5-羟基色氨酸x射线粉末衍射 晶体结构 

分 类 号：O76[理学—晶体学] O621.2