某金矿井下从业人员外周血淋巴细胞微核分析  

Analysis on CB Micronucleus in Peripheral Blood Lymphocytes of Workers in A Gold Mine

作　　者：马娅[1] 陈英民[1] 侯殿俊[1] 李海亮[1] 商希梅[1] 李洁清[1] 

机构地区：[1]山东省医学科学院放射医学研究所,山东济南250062

出　　处：《中国辐射卫生》2009年第4期401-402,共2页Chinese Journal of Radiological Health

基　　金：山东省科技攻关项目(2008GG10008002)

摘　　要：目的了解金矿井下从业人员的外周血淋巴细胞微核率的变化情况。方法用胞质分裂阻滞(CB)微核测试法分析我省某金矿井下凿岩等从业人员的外周血淋巴细胞微核变化情况。结果检查56名井下工作者的外周血淋巴细胞,微核细胞率为10.8‰,微核率为11.6‰,明显高于正常对照组(8.7‰,9‰)P<0.05。井下从业者各工龄组间和正常对照组比较统计学分析有显著性差异(P<0.05)。6～10a和20a以上工龄组的微核检出率明显高于不足5年的井下工龄组,差异有统计学意义(P<0.05),但其他工龄组间统计学分析意义不显著(P>0.05)。结论金矿井下从业人员的DNA遗传物质已产生不同程度的损伤效应。有必要进一步加强防治措施,最大限度的减少工作人员的职业危害。Objective To investigate the peripheral blood lymphocyte micronucleus rate changes of the underground gold mine workers.Methods Cytokinesis-block micronucleus test analysis of micronucleus rate changes in the peripheral blood lymphocyte was made in the staff of one gold mine in our province.Results The peripheral blood lymphocyte micronucleus cell rate was 10.8‰ in 56 underground workers,micronucleus rate of 11.6 ‰,significantly higher than that of the normal control group （8.7 ‰,9 ‰） P〈0.05.There are signifieant differences between the mine workers of various work age groups and the control group in statistical analysis （P〈0.05）.Micro-nuclear detection rate in workers of 610 years and over 20 years of work was significantly higher those under 5 years.There is a marked statistical significance （P〈0.05）,but there is no statisticall significance among other work age groups （P〉0.05）.Conclusion The gold mine employees in the DNA genetic material has been subject to varying degrees of damage.To minimize the occupational hazards,it is necessary to strengthen the prevention and control measures.

关 键 词：金矿 CB微核 职业危害 

分 类 号：R818.74[医药卫生—放射医学]