3-氧-乙酰-11-脱氧甘草次酸铝毒理学研究  

Experimental study on the toxicity of aluminium 3-o- acetyl- 11-deoxoglycyrrhate

作　　者：杨锦南[1] 刘春霞[1] 柴芳[1] 张玉林[1] 王彩兰 王素琴[1] 

机构地区：[1]新乡医学院药理教研室

出　　处：《新乡医学院学报》1998年第2期126-128,共3页Journal of Xinxiang Medical University

摘　　要：目的测定３－氧－乙酰－１１－脱氧甘草次酸铝（Ａｌｕｍｉｎｕｍ３－ｏ－ａｃｅｔｙｌ－１１－ｄｅｏｘｏｇｌｙｃｙｒｈ－ａｔｅ，ＡＤＡ）的半数致死量（ＬＤ５０）及对大鼠血清钠、钾浓度的影响。方法昆明小鼠６０只，体重２０±１ｇ，随机分６组，每组１０只，各组按不同剂量的ＡＤＡ０．２ｍｌ·１０ｇ－１灌胃，给药后按急性毒性实验法连续观察７ｄ。Ｗｉｓｔａｒ大鼠４０只，体重２００±１０ｇ，随机分４组，每组１０只。各组分别给０．５％羧甲基纤维素钠（ＣＭＣ）、生胃酮（Ｃａｒｂｅｎｏｘｏｌｏｎｅ，ＣＮ）和两个剂量的ＡＤＡ，早晚灌胃一次，连续１２ｄ后，处死大鼠取血，测血清钠、钾浓度。结果灌胃ＡＤＡ的ＬＤ５０为４４４４±８３１．５ｍｇ·ｋｇ－１。长期用药，ＡＤＡ未引起大鼠血清钠、钾浓度的明显变化，相反ＣＮ却显著降低血清钾浓度。结论ＡＤＡ引起急性致死性中毒的危险性甚小，长期用药未引起大鼠血清钠。Objective To measure the median lethal dose of aluminium 3-o-acetyl-11-deoxoglycyrrhate(ADA) and the effect on Na+ and K+ serum concentration in rats.Methods The 60 mice weighing 20±1g,were randomly divided into 6 groups which given orally different doses of ADA 0.2ml·10g^-1 respectively. Then the observation lasted 7days according to the acute toxic method. The 40 Wistar rats weighing 200 ±10g, were randomlydivided into 4 groups which were given 0.5% sodium cellothyll carboxymethylcellulose(CMC),carbenoxolone(CN) and two doses of ADA respectively. The route was given ig,twice a day,for 12 days.Then rats were killed and the blood was collected to measure Na^+ and K^+ concentrations in serum.Results The ig median lethal dose of ADA is 4444±831.5mg·kg^-1.Serum Na^+ and K^+ concentrations are not affected by ADA after the drug was　given orally for consecutive 12 days. But CN significantly decrease the K^+ concentration.

关 键 词：生胃酮 毒理学 甘草次酸铝 ADA 

分 类 号：R965.3[医药卫生—药理学] R975[医药卫生—药学]