259例临床分离念珠菌的耐药性分析  

Analysis of the drug resistance of 259 strains clinical isolated Candida

作　　者：石凤兰[1] 李俐佳[1] 宋丹[1] 董开秀[1] 伍贤鼎[1] 

机构地区：[1]贵州省贵阳市第一人民医院,550002

出　　处：《医学信息（下旬刊）》2010年第1期58-59,共2页Medical information

摘　　要：目的：了解我院分离到的真菌的分布和对常用抗真菌药物的敏感情况进行分析，以指导临床用药。方法：收集我院一年中分离到的念珠菌，菌种鉴定采用法国科马嘉公司生产的念珠菌显色培养基培养，根据菌落的形态、大小及颜色变化鉴定到种的水平；药物敏感性试验采用梅里埃公司的ATBFUNGUS3酵母真菌药敏试剂条（微量稀释法）。结果：收集患者首次分离真菌259株，其中白色念珠菌220株（84．9％），近平滑念珠菌22株（8．5％）、热带念珠菌n株（4．2％）、克柔念珠菌6株（2．3％）；所监测菌株对两性霉素B的耐药较低，对氟康唑、酮康唑、两性霉素B、伊曲康唑和制霉菌素的总耐药率分别为18．5％、25．9％、9．5％、18．5％和18．5％；白色念珠菌对以上五种药的耐药率分别为17．7％、24．1％、9．1％、19．1％和19．1％。结论：临床分离的念珠菌仍以白色念珠菌为主，常用抗真菌药物对所监测念珠菌仍有较好的抗菌活性。Objective ：To understand the isolated fungi＇s distribution and its sensitivity to the commonly used antifungal agents and to guide clinical medication. Method：The isolated Candida were collected for one year from our hospital , and Candida Color mediums produced by Kema Jia Corporation in the French were used in strain identification of species levels, according to the colony morphology, size and color changes . Drug sensitivity test were carried out with Meria＇s ATB FUNGUS3 yeast fungi susceptibility test strips （micro -dilution method）. Results：The first isolated fungi were 959 strains , including 220 strains Candida albicans （84. 9% ）, 22 strains Candicla parapsilosis （8.5%）, 11 strains Candida tropicalis （4.2%）, 6 strains Candida krusei （2.3%） ; Amphotericin B＇s drug resistant rate of the Monitoring strain was low ; the overall drug resistant rates of fluconazole, ketoconazole, amphotericin B, itraconazole and nystatin was respectively 18. 5%, 25.9% , 9.5%, 18.5% and 18.5% ; the above -mentioned five kinds of drug resistant rates of Candida albicans was respectively 17.7%, 24.1%, 9.1%, 19.1% and 19.1% . Conclusion： Clinical isolated Candida albicans is still the main ; the commonly used antifungal agents against the monitored Candida still have a better antimicrobial activity.

关 键 词：念珠菌 耐药性 药物敏感性试验 

分 类 号：R927[医药卫生—药学]