计算机重建白花前胡Ca^(2+)通道作用机制  

RECONSTRUOTION OF Ca^2+ WHOLE CELL CLAMP AND STUDY OFP·PRAERUBTORUM DUNN ON Ca^2+ CHANNEL

作　　者：董巍[1] 秦毅[1] 徐跃平[1] 张莹[1] 赵实 

机构地区：[1]中国医科大学生物物理教研室

出　　处：《中国医学物理学杂志》1998年第3期150-152,共3页Chinese Journal of Medical Physics

摘　　要：本文根据Ｂｅｅｌｅｒ－Ｒｅｕｔｅｒ方程，对Ｃａ２＋通道电流结合膜片钳实验数据进行计算机重建，并研究了中药白花前胡有效成份Ｐｄ－ＩａＣａ２＋通道的作用模式，为研究Ｃａ２＋通道电流及开关因子的动态过程提供了一个新方法。Abstract: According to Beeler-Reuter equation,we reconstruct action potental ionic currents and I-V curve combing with the experimental data of Ca^2+ whole cell clamp.we also study the P.Praerubtorum Dunn on Ca^2+ Channel.The results indicate that: 1.Pd-Ia as a Ca antagonists can shortenAPD,ERP,APD 20 and APD 50 absolutely but they can longen ERP relatively. 2.Pd-Ia as a Ca antagonists,subordinate to the similar law of effection and concentration:IC2+a(drug)/IC2+a=1ex-xhshere x=log C.when x=xh,IC2+a(drug)/IC2+a=0.5

关 键 词：Ca^2+电流 开关因子 I-V曲线 心脏电生理 

分 类 号：R331.38[医药卫生—人体生理学] R540.4[医药卫生—基础医学]