铅性肾损害效应生物标志物β_2-MG、NAG、RBP的相关影响因素研究  

Study on the influential factors of the β_2-MG、NAG and RBP evaluating the nephrotoxicity caused by lead

作　　者：苏素花[1] 蒋东方[1] 农康[1] 廖瑞庆[1] 

机构地区：[1]广西壮族自治区职业病防治研究院,南宁530021

出　　处：《中国临床新医学》2009年第12期1239-1242,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西壮族自治区科学技术厅自然基金项目(编号:200104)

摘　　要：目的研究β2-MG、NAG、RBP在铅性肾损害评价中的影响因素。方法采用相关分析或分组比较法。结果β2-MG、NAG、RBP与年龄、接铅工龄呈明显正相关(r依序为:0.221、0.230、0.433,0.359、0.419、0.365),β2-MG、RBP与血铅呈明显正相关(r依序为:0.419、0.354);另外三个指标间也有明显相关关系。结论应用RBP、β2-MG、NAG评价铅性肾损害时,应注意个体的年龄、接铅工龄的影响,并注意与血铅及其各指标间的相互关系。Objective To study the influential factors of the β2-MG,NAG and RBP evaluating the nephro- toxicity caused by lead. Methods In the study, the methods of the correlation analysis and group comparison were a- dopted. Results The data of the β2-MG, NAG and RBP are related to the age and receptive-lead standing （ r=0. 221,0. 230,0. 433,0. 359,0. 419,0. 365 ）. And the data of β2-MG and RBP related to the PbB （ r= 0. 419, 0. 354）. Moreover, the relations among the β2-MG,NAG and RBP were existing. Conclusion When the β2-MG, NAG and RBP are used to evaluate the nephrotoxieity caused by lead, the indexes are influenced by the age, receptive-lead standing and PbB.

关 键 词：铅性肾损害 Β2-MG NAG RBP 影响因素 

分 类 号：R595.2[医药卫生—内科学]