慢性乙型肝炎患者血清HBV DNA、ALT及透明质酸与肝组织病理的关系  

Relationship between level of serum HBV DNA,ALT,HA and pathological changes in liver tissues of patients with chronic hepatitis B

作　　者：刘红[1] 刘钦[1] 曹廷智[1] 乐晓华[1] 吴其恺[1] 聂广[1] 

机构地区：[1]深圳市第三人民医院肝病科,广东深圳518020

出　　处：《中西医结合肝病杂志》2009年第6期327-330,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨慢性乙型病毒性肝炎(CHB)患者血清HBV DNA、ALT(丙氨酸转氨酶)、HA(透明质酸)与肝组织病理的关系,为临床治疗提供一定的理论指导。方法:对127例CHB患者行肝组织病理、乙型肝炎病毒(HBV)免疫组化检查,并检测其血清HBV DNA、HBV-M、ALT、HA水平。结果:ALT对肝脏炎症程度的评估有意义(P<0.01),HA有助于判断CHB患者肝脏的炎症及纤维化程度(P<0.01),肝组织S0组与S1～4组、肝组织G0～1组与G2～4组的血清HBV DNA水平比较差异无显著性意义(P>0.05);HBcAg阳性组与阴性组的HBV DNA含量比较差异有显著性意义(P<0.01)。结论:血清HBVDNA水平与肝组织HBcAg表达有一致性,ALT正常或低水平者应争取肝组织活检,以便及时判断肝组织病理状况,把握治疗时机。Objective： To study the relationships between level of serum HBV DNA, ALT, HA and hapatic pathological and immunohistochemical changes in the patients with chronic hepatitis B. Methods： Pathological and immunohistochemical, examinations, of liver tissue liver function tests, serum HBV and HBV DNA detection were performed in 127 patients with chro- nic hepatitis B. Results： The inflammatory staging were significantly correlated with Alanine transaminase, the inflammatory staging and fihrotic scoring grading were significantly correlated with Hyaluronic acid, level of serum HBV DNA between the groups So and S1-4, and between the groups G0-1 and G2-4 were not significantly different. And the hepatic HBcAg positive group and HBeAg negative group were significantly different. Conclusion： Serum HBV DNA correlated with HBcAg expression in liver tissue, patients with normal or low serum ALT level should be encouraged to accept liver biopsy. It can determine the degree of liver inflammation and fibrosis and timing of treatment.

关 键 词：肝炎 乙型 慢性 肝炎 病毒性 人 肝/病理学 血清学试验 

分 类 号：R512.62[医药卫生—内科学] R450[医药卫生—临床医学] R446.1