糖尿病大鼠骨代谢的变化  

STUDY OF BONE METABOLISM IN STZ-DM RATS

作　　者：杨秀芳[1] 徐一甄[1] 方京冲[1] 周俊琪 史虹莉[1] 沈稚舟[1] 朱禧星[1] 

机构地区：[1]上海医科大学华山医院糖尿病研究室

出　　处：《上海医科大学学报》1998年第5期353-355,共3页Journal of Fudan University(Medical Science)

摘　　要：目的研究糖尿病早期骨代谢改变。方法测定６周实验性糖尿病（ＳＴＺ－ＤＭ）大鼠空腹血糖、ＨｂＡ１ｃ、胰岛素、钙离子浓度、骨钙素、降钙素、ＰＴＨ和维生素Ｄ３。收集２４ｈ尿，测定白蛋白、肌酐、吡啶酚。结果糖尿病大鼠与正常对照组相比，血清钙浓度显著升高［（１３５．８５±１１．２８）对（１１７．２１±６．５２）ｍｇ／Ｌ，Ｐ＜０．０１］，骨钙素水平升高［（０．０７±０．０４）对（０．０５±０．０１）ｎｇ／ｍｌ，Ｐ＜０．０５］，维生素Ｄ３水平显著降低［（７．６３±１．８８）对（１１．５５±４．１１）ｎｇ／ｍｌ，Ｐ＜０．０５］，尿吡啶酚／肌酐显著降低［（４．７９±０．７５）对（７５．８４±６０．６７）ｎｍｏｌ／ｍｍｏｌ，Ｐ＜０．０１］；而血清降钙素和甲状旁腺素水平改变无统计学意义。结论糖尿病状态下存在骨代谢异常，主要表现为维生素Ｄ３降低、骨钙素升高及尿吡啶酚水平降低。PURPOSE To investigate the bone metabolism in STZ-DM (streptozocin induced diabetes mellitus) rats. METHODS Twenty Sprague-Dawley rats were radomly divided into 2 groups, 12 STZ-DM rats and 8 controls. We measured serum vitamin D 3, parathyroid hormone, calcitonin and osteocalcin, as well as urinary pyridinium crosslinks. RESULTS Compared to the controls, serum osteocalcin in STZ-DM rats significantly elevated, while serum vitamin D 3 and urinary pyridinium crosslinks significantly decreased. CONCLUSIONS There were bone metabolic changes in early stage of diabetes mellitus, presenting as increased osteocalcin, decreased vitamin D 3 and pyridinium crosslinks. It suggested that diabetic osteoporosis might relate to those changes.

关 键 词：糖尿病 维生素D3 骨质疏松 大鼠 骨钙素 

分 类 号：R587.2[医药卫生—内分泌] R681.02[医药卫生—内科学]