糖尿病性阳萎动物模型的建立  

MAKING EXPERIMENTAL ANIMAL MODELS OF IMPOTENCE WITH DIABETES MELLITUS

作　　者：王为服[1] 张元芳[1] 丁强[1] 徐一甄[1] 方京冲[1] 孔宪国[1] 史红莉[1] 

机构地区：[1]上海医科大学华山医院泌尿外科

出　　处：《上海医科大学学报》1998年第5期385-388,共4页Journal of Fudan University(Medical Science)

摘　　要：目的为临床及科研提供糖尿病（ＤＭ）性阳萎动物模型。方法应用ｓｐｒａｇｕｅ－ｄａｕｌｅｙ大鼠腹腔内注射链脲佐菌素（ＳＴＺ）制造ＤＭ动物模型。根据临床表现，尿糖、血糖及糖化血红蛋白来综合诊断ＤＭ。注射脱水吗啡（ＡＰＯ）后观察６周（Ⅰ组）、８周（Ⅱ组）、１２周（Ⅲ组）时，ＤＭ组、空白对照组（ＮＤＭ）及ＳＴＺ药物对照组（ＳＴＺ）阴茎勃起及打呵欠的情况。结果３组中ＤＭ组与ＮＤＭ或ＳＴＺ组比，阴茎勃起率、阴茎勃起次数及打呵欠次数明显降低（Ｐ＜０．００１，Ｐ＜０．０１及Ｐ＜０．０１）；而ＮＤＭ与ＳＴＺ组相比无显著性差异（Ｐ＞０．０５）。３组ＤＭ组阴茎勃起率两两相比有显著性差异（Ｐ＜０．０５）。即随ＤＭ病程延长，阴茎勃起率明显下降。结果提示ＤＭ严重影响阴茎勃起功能，且与其病程明显相关。PURPOSE To provide experimental animal modal of impotence with diabetes mellitus (DM) for clinical and experimental researches. METHODS Sprague-Dawley rats were injected intraperitoneally with streptozotocin (STZ)to make experimental models of DM. DM was diagnosed by clinical characteristies, urine glucose,blood glucose, and HbAlc.Penile erections and yawns of the DM, control(NDM)and STZ control group(STZ) after apomorphine(APO) injection were observed at the sixth, eighth and twelfth weeks starting from the fourth day of injecting STZ. RESULTS Compared with NDM or STZ group,the ratio of penile erections and the number of penile erections and yawns of the DM group decreased significantly, no significant difference between the NDM and STZ groups was observed decreased. The ratio of penile erections of the DM group decreased significantly with the increasing of the time course. CONCLUSIONS APO injection can be used to select animal model of impotence in the experimental DM model for clinical and experimented researches.

关 键 词：糖尿病 阳萎 动物模型 

分 类 号：R587.2[医药卫生—内分泌] R698.1[医药卫生—内科学]