替考拉宁经验治疗老年重症社区获得性肺炎降低治疗失败率的回顾分析  

Teicoplanin Treatment of Severe Community-acquired pneumonia among Elderly:A Retrospective Analysis

作　　者：谢逸群[1] 邓洪波[1] 张萍[1] 李友元[1] 曾艺[1] 易玉新[1] 

机构地区：[1]中南大学湘雅二医院老年病科,湖南长沙410011

出　　处：《中华医院感染学杂志》2009年第24期3410-3413,共4页Chinese Journal of Nosocomiology

摘　　要：目的了解替考拉宁经验治疗老年重症社区获得性肺炎的合理性。方法筛选179例老年重症社区获得性肺炎住院患者,分列替考拉宁治疗组和非替考拉宁治疗组,分析其临床资料和抗菌药物经验治疗情况,比较两组PSI评分、治疗5 d后疗效的差异。结果替考拉宁治疗组67例,非替考拉宁治疗组112例,两组PSI评分差异无统计学意义,替考拉宁治疗组治疗总失败率为23.9%,非替考拉宁治疗组治疗总失败率为37.5%,两组差异有统计学意义(P<0.05);替考拉宁联合三代头孢菌素治疗失败率为19.4%,低于单用三代头孢菌素治疗失败率的50.0%(P<0.01),也低于三代头孢菌素联合其他抗菌药物治疗失败率的32.1%(P<0.01)。结论替考拉宁经验性治疗降低了老年重症社区获得性肺炎治疗失败率。OBJECTIVE To evaluate the rationality of teicoplanin for the empirical treatment of severe community-acquired pneumonia（CAP） in the aged.METHODS Totally 179 hospitalized cases of severe CAP were enrolled and divided into two groups,teicoplanin treatment group（67 cases） and non-teicoplanin treatment group（112 cases）,whose clinical data and antibiotic empirical treatment were analyzed respectively,compared their PSI scores and clinical outcomes after 5 day′s therapy.RESULTS The PSI scores had no significant difference of two groups.The total treatment failure rate in teicoplanin treatment group was 23.9%,lower than that in non-teicoplanin treatment group.The treatment failure rate of teicoplanin combining the third generation cephalosporin treatment cases was 19.4%,lower than that in single use of cephalosporin（50.0%）,also less than that in the cases of cephalosporin combining other antibiotics therapy,which accounted for 32.1%.CONCLUSIONS The use of teicoplanin may reduce treatment failure rate of severe CAP among aged.

关 键 词：社区获得性肺炎 老年 替考拉宁 革兰阳性菌 

分 类 号：R978.1[医药卫生—药品]