中药活血补肾方对实验性糖尿病肾病的保护作用探讨  

Study on protective effect of Huoxuebushen prescription on experimental diabetic nephropathy

作　　者：赵存杰[1] 常红[2] 高帆[2] 孙国强[2] 韩丽芳[1] 刘美兰[1] 王玉梅[1] 孙丽梅[1] 郭建华[1] 李卫川[1] 

机构地区：[1]河北省邯郸市第一医院,河北邯郸056002 [2]河北省中医药研究院,河北石家庄050031

出　　处：《现代中西医结合杂志》2010年第3期275-276,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察活血补肾方对不同实验动物糖尿病模型的保护作用。方法观察不同剂量(2.45 g/kg,4.9 g/kg)的活血补肾方对四氧嘧啶糖尿病小鼠、肾上腺素性高血糖小鼠、链脲菌素糖尿病肾病大鼠血糖2、4 h尿蛋白等指标的影响,并与优降糖作对照观察。结果活血补肾方对不同糖尿病模型均具有改善作用,具有量效关系。结论中药活血补肾方可能通过不同作用途径达到改善糖尿病肾病的目的。Objective It is to observe the protective effect of Huoxuebushen prescription in different experimental animal of diabetes.Methods The influence of different dosages（2.45 g/kg,4.9 g/kg） of Huoxuebushen prescription to alloxan diabetic mice,adrenaline high blood sugar mice and streptozotocin diabetic nephropathy rats in blood glucose and 24h urine protein,and compared with glibenclamide in control.Results Huoxuebushen prescription has the improvement function to different diabetes model;there was a positive dose-effect relationship.Conclusion The Huoxuebushen prescription may achieve the purpose of improvement of diabetic nephropathy through different pathways.

关 键 词：活血补肾方 糖尿病肾病 

分 类 号：R965.2[医药卫生—药理学]