甲状腺癌的体表傅里叶变换红外光谱研究  

Surface detection of thyroid cancer by Fourier transform infrared spectroscopy

作　　者：刘亚奇[1] 徐怡庄[2] 孙启刚[1] 张小青[1] 徐智[1] 张元福[2] 吴瑾光[2] 周孝思[1] 凌晓锋[1] 

机构地区：[1]北京大学第三医院普外科,100191 [2]北京大学化学与分子工程学院

出　　处：《中华肿瘤杂志》2009年第12期908-910,共3页Chinese Journal of Oncology

基　　金：基金项目：北京市自然科学基金（2072020）

摘　　要：目的探讨术前采用傅里叶变换红外光谱（FTIR）技术诊断甲状腺癌的临床意义。方法联合运用衰减全反射（ATR）探头与中红外光纤、FTIR光谱仪，测定15例甲状腺癌患者（甲状腺癌组）与14例甲状腺正常者和25例单侧良性甲状腺病变者（正常甲状腺组）甲状腺皮肤表面的FTIR光谱，比较两组11个波峰的峰位及相对峰强等22个指标，找出甲状腺癌体表光谱的特征。结果与正常甲状腺体表光谱相比，甲状腺癌体表光谱中P1743发生明显蓝移（向高波数移动，P=0．041），P1250发生明显红移（向低波数移动，P=0．023）。甲状腺癌体表光谱相对峰强I1546／I1460（P=0．030）、I1250／I1460）（P=0．000）、I1120／I1460（P=0．018）和I1080／I1460（P=0．008）明显升高；1340cm^-1波峰在甲状腺癌体表光谱中的出现概率显著降低（P=0．000）。结论甲状腺癌组与正常甲状腺组的甲状腺体表光谱在多个波峰的峰位或相对峰强方面存在显著差异。FTIR技术快速、无创，有望成为甲状腺癌筛查的重要手段。Objective To explore a novel non-invasive method in detection of thyroid cancer by Fourier transform infrared （FTtR） spectroscopy. Methods Surface FTIR spectra of 15 cases of thyroid cancer and 51 cases of normal subjects were collected. 22 variables of 11 bands including peak positions and relative intensities were measured and all data were statistically analyzed. Results In the cancer group： （ 1 ） the peak position of 1743 cm^-1 was shifted toward higher wave number （ P 〈 0.05 ） , and that of 1250 cm^-1 to the lower （P 〈 0.05 ） , when compared to those of normal ones. （2） The relative intensity ratios of I1546/I1460 , I1250 /I1460, I1120/I1460, I1080/I1460 were significantly increased （P 〈0.05）. （3） The presence rate of band of 1340 cm^-1 was significantly decreased （P 〈 0.05 ）. Conclusion FTIR surfaee spectra may become a novel powerful non-invasive approach of detecting thyroid cancer in regular routine check-up.

关 键 词：甲状腺肿瘤 光谱 傅里叶变换红外 诊断 

分 类 号：R686[医药卫生—骨科学]