2009甲型流行性感冒病毒感染者常规免疫学检测的临床意义  

Clinical significance of routine immunological markers in patients infected with influenza type A H1N1 virus

作　　者：沈芳[1] 金鑫[1] 毛会军[1] 高琼[1] 陈戴红[1] 

机构地区：[1]上海市(复旦大学附属)公共卫生临床中心,上海201508

出　　处：《微生物与感染》2009年第4期198-202,共5页Journal of Microbes and Infections

基　　金：上海市卫生局科研课题(2008WSZB007)

摘　　要：本文旨在探讨2009甲型流行性感冒(流感)病毒(H1N1)感染者的常规免疫学指标与健康人的差异。采用流式细胞术检测32名甲型H1N1感染者外周血不同T细胞亚群,同时进行血清特定蛋白检测及血细胞计数。结果显示,与健康者相比,甲型H1N1感染者外周血CD3+、CD3+CD4+、CD3+CD8+T细胞(cells/μl)显著降低,血清补体成分C3、C4(g/L)及C反应蛋白(mg/L)显著升高,血小板、白细胞、淋巴细胞与嗜酸性粒细胞显著降低,单核细胞显著升高。结果提示,甲型H1N1感染者的常规免疫学指标出现异常发展趋势。The paper aimed to investigate the differences in immunological evaluations between influenza type A H1N1 virus-infected patients and uninfected individuals. T-cell subtypes in peripheral blood from 32 H1N1-infected patients were quantified using flow cytometry. Specific protein markers in serum were deteimined and blood ceils were counted. The results showed that mean counts of CD3^＋ , CD3 ＋ CD4^ ＋ , and CD3 ^＋ CD8 ^＋T cells in peripheral blood of H1N1-infected patients were significantly reduced compared with those in uninfected individuals whereas serum complement components （C3 and CA） and C-reaction protein were significantly increased in H1N1-infected patients. Furthermore, platelets, leukocytes, lympbocytes, and eosinophilic cells were significantly decreased, while monocytes were significantly increased in this population. It is indicated that routine immunological evaluation has clinical significance in H1N1-infected patients.

关 键 词：甲型流行性感冒病毒H1N1 T细胞 新现和再现传染病 

分 类 号：R511.7[医药卫生—内科学] R446.6[医药卫生—临床医学]