多潘立酮对功能性消化不良患者阻抗式胃动力的影响  

Effects of domperidone on impedance gastric motility of patients with functional dyspepsia

作　　者：罗访[1] 刘纯伦[1] 李章勇[2] 周成会[1] 周旭春[1] 

机构地区：[1]重庆医科大学附属第一医院消化内科,重庆400016 [2]重庆邮电大学生物信息学院,重庆400065

出　　处：《中国实用内科杂志》2010年第1期58-60,共3页Chinese Journal of Practical Internal Medicine

基　　金：国家自然科学基金(60471041)

摘　　要：目的观察多潘立酮对功能性消化不良(FD)餐后不适综合征(PDS组)和上腹疼痛综合征(EPS组)临床症状和胃动力的影响。方法对2008年10月至2009年4月重庆医科大学附属第一医院消化内科门诊57例FD患者行症状分型和评分、检测餐后胃电和胃阻抗,多潘立酮10mg每日3次治疗2周和4周后,再次评分并复查胃动力。结果治疗2周后,PDS组和EPS组餐后饱胀不适、早饱感、上腹痛、上腹烧灼感症状较治疗前显著改善(P<0.05);4周后除PDS组上腹烧灼感和EPS组早饱感、上腹痛外余症状均进一步改善(P<0.05)。治疗前和治疗后2周及4周PDS组和EPS组的胃电中频百分比差异均有统计学意义(P<0.05)。PDS组治疗2周后胃阻抗中频百分比较治疗前显著提高,4周后进一步提高(P<0.05);治疗4周后,EPS组胃阻抗中频百分比显著高于治疗前和治疗后2周(P<0.05)。结论多潘立酮治疗4周后FD患者的临床症状、胃电和胃阻抗显著改善,明显优于治疗后2周。Objective To observe the effects of domperidone on the symptoms and impedance gastric motility of patients with functional dyspepsia （FD） subtypes-postprandial distress syndrome （PDS） and epigastric pain syndrome （EPS）. Methods A total of FD 57 patients （ according to Rome Ⅲ） ,who were treated in our hospital during Oct. 2008 to Apri. 2009, were included in the present study. The symptoms of patients FD were scored before and after treatment with domperidone for 2 and 4 weeks. Domperidone 10 mg was given 3 times daily. The postprandial gastric motility was tested before and after domperidone treatment for comparison. Results Domperidone significantly decreased the scores of postprandial abdominal distention, early satiety, upper abdominal pain and abdominal burning in PDS and EPS group 2 weeks after domperidone treatment （ P 〈 0. 05 ） ; d weeks after treatment, all the symptoms were improved except for the upper abdominal burning in the PDS group and early sa- tiety, upper abdominal pain in the EPS group （P 〈 0. 05 ）. The differences in percentages of the power of electrogastrogram dominant frequency were significantly different between PDS and EPS patients before and after treat- ment for 2 and 4 weeksP 〈 0.05 ）. Two weeks after treatment, the percentages of the power of the dominant frequency for impedance gastrogram in PDS patients were significantly higher than that before treatment,and signifi- cantly lower than that 4 weeks after treatment （ P 〈 0. 05 ）. The percentages of the power of the dominant frequency of impedance gastrogram in EPS patients before and 2 weeks after treatment were significantly lower than those 4 weeks after treatment （P 〈 0. 05 ）. Conclusion Domperidone can significantly relieve the clinical symptoms,improve electrical signal and impedance gastric motility in PDS and EPS patient after 4 weeks, with the effect obviously better than that after 2weeks.

关 键 词：功能性消化不良 多潘立酮 阻抗式胃动力 

分 类 号：R5[医药卫生—内科学]