ACTN3基因C1747T多态位点作为举重运动员选材用分子标记的可行性研究  

Feasible Research of the Gene Mark for Chinese Weightlifting Athlete Selection through the SNP C1747T in ACTN3 Gene

作　　者：杨晓琳[1] 胡扬[1] 李燕春[1] 魏悦爽[1] 

机构地区：[1]北京体育大学,北京100084

出　　处：《体育科学》2010年第1期70-73,共4页China Sport Science

基　　金：科技部支撑计划(2005DKA21300-9)

摘　　要：目的:选取ACTN3基因C1747T多态位点进行解析,筛选中国举重运动员选材用分子标记。方法:提取94名中国北方汉族优秀举重运动员全血DNA,应用PCR-RFLP方法解析C1747T多态位点,通过χ2检验与206名普通对照组进行分析。结果:94名中国北方汉族优秀举重运动员的C1747T多态位点的基因型分布经χ2检验符合H-W平衡(χ2=2.04;df=2;P>0.05)。优秀举重运动员组与普通对照组ACTN3基因C1747T多态位点的基因型分布具有显著性差异(P=0.031,P<0.05),等位基因分布也具有显著性差异(P=0.022,P<0.05)。与普通对照组(CC基因型:31%;C等位基因:56%)相比,举重运动员组CC基因型(47%)以及C等位基因(66%)的出现频率较高。结论:我国北方汉族人群ACTN3基因C1747T多态位点的CC基因型和C等位基因与优秀的力量素质显著相关。可以将ACTN3基因C1747T多态位点的CC基因型作为中国北方汉族举重运动员的选材用分子标记。The purpose of this study is to filter the genetic mark for Chinese weightlifting athlete selection through analyzing the single nucleotide polymorphism C1747T in ACTN3 gene. Methods： 94 elite weightlifting athletes of Han nationality from northern part of China were selected and distribution of genotype was got using PCR-RFLP. ACTN3 genotype and allele frequencies were compared to 206 controls. Results： The frequencies of the ACTN3 CC genotype （47 vs. 31% ;P=0. 031;P〈0.05） and C allele （66 vs. 56%;P=0. 022;P〈 0.05） were significantly higher in weightlifting athletes compared to controls. In conclusion, ACTN3 C1747T polymorphism was associated with weightlifting athlete status in Chinese. Conclusion：The SNP C1747T could be one of the genetic marks for Chinese weightlifting athlete selection.

关 键 词：ACTN3 力量素质 单核苷酸多态 基因型 快肌纤维 举重 

分 类 号：G804.7[文化科学—运动人体科学]