659例抗微生物药物不良反应报告回顾性分析  

Retrospective Analysis of 659 Cases of Adverse drug Reactions Caused by Anti-Microbacteria Drugs

作　　者：毕津莲[1] 黄明菊[1] 李湘斌[1] 

机构地区：[1]南华大学附属第一医院药剂科,湖南衡阳421001

出　　处：《药物流行病学杂志》2010年第1期27-29,共3页Chinese Journal of Pharmacoepidemiology

基　　金：湖南省衡阳市科学技术发展计划项目(编号:2005KS01-023)

摘　　要：目的:了解我院抗微生物药不良反应的情况,为临床合理用药提供参考。方法:回顾性分析我院2004～2008年的抗微生物药物不良反应报告。结果:659例药品不良反应(ADR)报告中,以头孢菌素类药发生例数最多(35.51%),其次为喹诺酮类(25.34%)和青霉素类(19.73%);ADR的给药途径主要是静脉给药(88.01%);涉及的系统器官主要为皮肤及附件(53.87%)。结论:抗微生物药不良反应的发生与药物类型、给药途径、用药频率等密切相关,应提高医护人员对ADR的警惕性和不良反应监测水平,加强对抗微生物药物不良反应的监测,预防和及时报告ADR,以保证用药安全性和合理性。Objective： To study the occurrence of adverse drug reactions （ADR） caused by anti-microbacteria drugs in order to improve the rational drug use level in the clinic. Method： A total of 659 cases of ADRs caused by antimicrobacteria drugs in our hospital from 2004 to 2008 were classified and statistically analyzed. Result： Of the 659 cases, leading the list were cephalosporins （35.51%）, followed by quinolones （25.34%） and penicillins （ 19.73% ） ; intravenous infusion （88.01%） was the main route of administration; and the main types of adverse drug reactions （ADR） were lesions of skin and accessories （53.87%）. Conclusion： The ADRs was closely associated with the kinds of drugs, route of administration, frequency of administration, and so on. Therefore, for the sake of the rational drug use of anti-microbacteria drugs in the clinic, health care providers should maintain high vigilance to ADRs, improve the monitoring level of ADRs, attach great importance to ADR monitoring of anti-microbacteria drugs, prevent the occurrence of ADRs, and report ADRs in time when they occur.

关 键 词：抗微生物药 药品不良反应 回顾性分析 合理用药 

分 类 号：R978.1[医药卫生—药品]