组蛋白变体及组蛋白分子伴侣的研究进展  

Development on the Histone Variants and Histone Chaperones

作　　者：李微微[1] 郭东林[1] 

机构地区：[1]哈尔滨师范大学生命科学与技术学院,哈尔滨150025

出　　处：《中国农学通报》2010年第1期56-61,共6页Chinese Agricultural Science Bulletin

基　　金：哈尔滨师范大学青年骨干教师科研项目"拟南芥FAD8基因在叶绿体基因组表达提高植物低温抗性研究"(08KXQ-05);哈尔滨师范大学大学生创新基金"大蒜微核技术体系的建立"(2007048)

摘　　要：组蛋白作为核小体的基本组分,是染色质的结构和功能必需的。此文总结了不同时期的染色质核小体所进行的组蛋白变体的组装,核小体的空间构象和稳定性的改变及对基因转录的激活或沉默和DNA修复等的影响。简述了核小体的去组装和重新组装过程中组蛋白分子伴侣的介导,认为组蛋白分子伴侣对于染色质结构稳定和基因表达调控非常重要。Histones, as basic components of nucleosome , are essential to chromatin structure and function. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, these variants change the conformation and stability of nucleosome to facilitate transcriptional activation or deactivation, DNA repairing, and others. The histone chaperones are needed during DNA replication progess for disassembly and rebuilding the chromatin structure. the histone chaperones are very important to the chromation structure stability and gene expression.

关 键 词：核小体 组蛋白变体 组蛋白分子伴侣 

分 类 号：Q518.4[生物学—生物化学]