基于灰色理论的漂浮性海藻酸钠微球药物缓释模型  

Studies on Controlled Release of Floatable Sodium Alginate Microspheres Based on Grey System Theory

作　　者：王贤明[1] 吴跃进[2] 蔡克周[2] 余增亮[2] 

机构地区：[1]温州大学瓯江学院信息系,浙江温州325035 [2]中国科学院离子束生物工程学重点实验室,安徽合肥230031

出　　处：《数学的实践与认识》2009年第23期86-91,共6页Mathematics in Practice and Theory

基　　金：中科院方向性项目(KSCXZ-SW-324)

摘　　要：以阿维菌素(AVM)为囊芯材料,海藻酸钠(SA)为包埋材料,通过添加发泡剂的形式,在C a2+的交联浴中制备了漂浮性SA微球.通过实验对漂浮性SA微球中AVM的释放情况进行检测,并应用灰色理论的GM(1,1)模型对微球的药物缓释性能进行了模拟和预测,结果显示模型的模拟值和预测值与实验数据的相对误差较小.表明灰色理论模型可用于模拟和预测SA微球的药物释放过程.A kind of floatable microspheres based on sodium alginate,avermectin and blowing agent was prepared by crosslinking the mixing solution with Ca^2＋.GM（1,1） models for controlled-realse were established by applying the theoretical principles of grey system theory.These models were used to imitate the controlled release behavior,the predicting values and simulated values matched the factual values very well.It showed that the grey system theory could be used to imitate and predict the controlled release behavior.

关 键 词：灰色理论 数学模拟 缓释 海藻酸钠 微球 

分 类 号：R944[医药卫生—药剂学] N941.5[医药卫生—药学]