黄酮类化合物杨梅酮促进大鼠海马长时程增强的作用  

Flavonoid myrisetin promotes long-term potentiation in rat hippocampal CA1 region in vivo

作　　者：贺文彬[1,2] 张俊龙[1] 薛薇[2] 胡金凤[2] 王晓峰[2] 陈乃宏[2] 

机构地区：[1]山西中医学院,太原030024 [2]中国医学科学院药物研究所,北京100050

出　　处：《中国新药杂志》2009年第24期2306-2308,2315,共4页Chinese Journal of New Drugs

基　　金：国家重大新药创制重大专项(2008ZX09101);国家自然科学基金重点项目(广东联合基金)(U0832008);山西省青年科技研究基金(2007021043)

摘　　要：目的:研究黄酮类化合物杨梅酮对海马CA1区突触可塑性的影响。方法:采用立体定位仪固定大鼠头部,按照脑立体定位图谱确定刺激电极坐标和记录电极坐标,在体电生理技术检测海马CA1区长时程增强。结果:黄酮类化合物杨梅酮对强高频刺激(100 pulse 100Hz)诱导的长时程增强无显著影响;单独给予弱高频刺激(20 pulses 100 Hz)不能诱导出长时程增强,杨梅酮口服作用30 min后,应用该强度的弱刺激能够成功诱导出长时程增强。结论:黄酮类化合物杨梅酮能够易化弱高频刺激诱导出长时程增强现象,具有潜在的益智作用。Objective：To study the effect of flavonoid myrisetin on long-term potentiation （LTP） in rat hippocampal CA1 region in vivo. Methods： Stereotaxic apparatus was used to fix the head of rat. The coordinators of stimulation and recoarding electrodes were aligned according to brain stereotaxic atlas. LTP was tested by in vivo electrophysiological technique. Results： Oral administration of flavonoid myrisetin had no effect on the induction of LTP by the strong tetanus with 100 pulses at 100 Hz, but promoted the induction of LTP by the weak tetanus with 20 pulses at 100 Hz, which alone did not successfully induce LTP. Conclusion： Oral administration of flavonoid myrisetin can promote the hippocamal synaptic plasticity.

关 键 词：黄酮类化合物 杨梅酮 海马 长时程增强 

分 类 号：R964[医药卫生—药理学] R971[医药卫生—药学]