注射用利培酮微球对精神分裂症患者生活质量改善作用的研究  

Improving effect of long-acting risperidone injection on quality of life in patients with schizophrenia

作　　者：何瑞荣[1] 贾竑晓[1,2] 王刚[1] 朱虹[1] 徐敏杰[1] 卜力[1] 许英[1] 王建勤[1] 张燕敏[1] 

机构地区：[1]首都医科大学附属北京安定医院,北京100088 [2]北京大学心理系,北京100871

出　　处：《中国新药杂志》2009年第24期2327-2330,共4页Chinese Journal of New Drugs

摘　　要：目的:研究注射用利培酮微球对精神分裂症患者生活质量的改善作用。方法:54名受试者随机分为两组,分别给予注射用利培酮微球和氟哌啶醇片治疗。注射用利培酮微球组在开始注射之前3d给予利培酮口服液治疗,患者对利培酮口服液无过敏反应后给予注射用利培酮微球治疗,注射之日为基线,基线后第3周渐减利培酮口服液用量,第4周停用口服液治疗。分别在基线期、第4,8,12,16周进行PANSS、生活质量与满意度量表及锥体外系症状量表(ESRS)评分,并分析结果。结果:注射用利培酮微球组与氟哌啶醇组各时点PANSS量表分与基线相比均有显著性差异(F=4.439,P=0.013),但两组间差异不具显著性(F=2.013,P=0.162)。注射用利培酮微球组生活质量及满意度评分的改善与基线相比有显著性差异(F=7.358,P=0.000),而氟哌啶醇组的这种差异不显著。注射用利培酮微球组在第16周时生活质量及满意度评分优于氟哌啶醇组(P<0.05)。氟哌啶醇组各时点ESRS评分与基线相比具显著性差异(F=45.93,P=0.000),而注射用利培酮微球组这种差异不显著。组间比较显示氟哌啶醇组ESRS评分明显高于注射用利培酮微球组(F=50.589,P=0.000)。结论:注射用利培酮微球对生活质量及满意度的改善作用优于氟哌啶醇,两者在改善PANSS量表分的临床疗效相当,但注射用利培酮微球所引起的锥体外系反应更轻微。Objective： To investigate the improving effect of long-acting risperidone injection on quality of life in patients with schizophrenia. Methods：Patients were randomly divided into two groups, and treated with either risperidone long-acting injection （ n = 27） or haloperidol （ n = 27）. The clinical symptoms, PANSS, Quality of Life Enjoyment and Satisfaction Questionnaire, and ESRS were evaluated at 4 weeks of follow-up intervals for 16 weeks. Results ： In both groups, PANSS scores were significantly improved （ F = 4. 439, P = 0.013 ） , and there was no significant difference between two groups （F = 2. 013 ,P=0. 162）. However, long-acting risperidone injection significantly improved the scores of Quality of Life Enjoyment and Satisfaction Questionnaire （ F = 7. 358, P = 0. 000） as compared with baseline values, but haloperidol did not show significant improvement. Long-acting risperidone injection improved the scores of Quality of Life Enjoyment and Satisfaction Questionnaire better than haloperidol at week 16 （P 〈 0.05 ）. In addition, long-acting risperidone injection had less ESRS than haloperidol （ F =50. 589,P = 0. 000）. Conclusion： Long-term treatment with long-acting risperidone injection improves Quality of Life Enjoyment and Satisfaction Questionnaire better than haloperidol. Both long-acting risperidone injection and haloperidol show similar efficacies on schizophrenia as evaluated by total PANSS score,but long-acting risperidone injection causes less ESRS.

关 键 词：精神分裂症 生活满意度 注射用利培酮微球 

分 类 号：R971.4[医药卫生—药品]